Gene: APOE (apolipoprotein E) Homo sapiens
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Symbol: APOE
Name: apolipoprotein E
Description: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AD2; Alzheimer disease 2 (APOE*E4-associated, late onset); apo-E; ApoE4; apolipoprotein E3; LDLCQ5; LPG; MGC1571
Orthologs:
Mus musculus (house mouse) : Apoe (apolipoprotein E)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apoe (apolipoprotein E)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoe (apolipoprotein E)
Pan paniscus (bonobo/pygmy chimpanzee) : APOE (apolipoprotein E)
Canis lupus familiaris (dog) : APOE (apolipoprotein E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoe (apolipoprotein E)
Sus scrofa (pig) : APOE (apolipoprotein E)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SD-Apoetm1(APOE*)Sage  
QTLs:   SCL22_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,905,749 - 44,909,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371945,409,039 - 45,412,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,100,879 - 50,104,490 (+)NCBINCBI36hg18NCBI36
Build 341950,100,878 - 50,104,489NCBI
Celera1942,213,361 - 42,216,972 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1941,839,825 - 41,843,436 (+)NCBIHuRef
CHM1_11945,411,760 - 45,415,406 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Candidate Gene Status
Comparative Map Data
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Sequence

Nucleotide Sequences