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Gene: APOE (apolipoprotein E) Homo sapiens
Symbol: APOE
Name: apolipoprotein E
Description: Exhibits several functions, including amyloid-beta binding activity; anion binding activity; and lipoprotein particle receptor binding activity. Involved in several processes, including regulation of lipid transport; regulation of protein metabolic process; and regulation of synapse organization. Localizes to several cellular components, including low-density lipoprotein particle; synaptic cleft; and triglyceride-rich plasma lipoprotein particle. Implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Biomarker of several diseases, including Lewy body dementia; beta thalassemia; diabetes mellitus (multiple); end stage renal failure; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AD2; Alzheimer disease 2 (APOE*E4-associated, late onset); apo-E; ApoE4; apolipoprotein E3; LDLCQ5; LPG; MGC1571
Mus musculus (house mouse) : Apoe (apolipoprotein E)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apoe (apolipoprotein E)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoe (apolipoprotein E)
Pan paniscus (bonobo/pygmy chimpanzee) : APOE (apolipoprotein E)
Canis lupus familiaris (dog) : APOE (apolipoprotein E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoe (apolipoprotein E)
Sus scrofa (pig) : APOE (apolipoprotein E)
Chlorocebus sabaeus (African green monkey) : APOE (apolipoprotein E)
Heterocephalus glaber (naked mole-rat) : Apoe (apolipoprotein E)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SD-Apoetm1(APOE*)Sage  
QTLs:   SCL22_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1944,905,791 - 44,909,393 (+)EnsemblGRCh38hg38GRCh38
GRCh381944,905,796 - 44,909,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371945,409,039 - 45,412,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,100,879 - 50,104,490 (+)NCBINCBI36hg18NCBI36
Build 341950,100,878 - 50,104,489NCBI
Celera1942,213,361 - 42,216,972 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1941,839,825 - 41,843,436 (+)NCBIHuRef
CHM1_11945,411,760 - 45,415,406 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated