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Gene: HSPA1B (heat shock protein family A (Hsp70) member 1B) Homo sapiens
Symbol: HSPA1B
Name: heat shock protein family A (Hsp70) member 1B
Description: Exhibits several functions, including ATP binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including regulation of RNA metabolic process; regulation of microtubule cytoskeleton organization; and regulation of signal transduction. Localizes to several cellular components, including the aggresome; microtubule organizing center; and nuclear speck. Colocalizes with the COP9 signalosome. Implicated in several diseases, including brain ischemia; obesity; senile cataract; toxic shock syndrome; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ54328; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; heat shock 70 kDa protein 1B; heat shock 70 kDa protein 2; heat shock 70kd protein 1a; heat shock 70kD protein 1B; heat shock 70kDa protein 1B; HSP70-1; HSP70-1/HSP70-2; HSP70-1B; HSP70-2; HSP70.1; HSP70.1/HSP70.2; HSP70.2; HSP72; HSPA1; HSPA1A; HSX70
Mus musculus (house mouse) : Hspa1b (heat shock protein 1B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hspa1b (heat shock protein family A (Hsp70) member 1B)  Alliance
Canis lupus familiaris (dog) : HSP70 (heat shock protein 70)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa1b (heat shock protein family A (Hsp70) member 1B)
Chlorocebus sabaeus (African green monkey) : HSPA1B (heat shock protein family A (Hsp70) member 1B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl631,827,738 - 31,830,254 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,827,738 - 31,830,254 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,789,964 - 31,798,032 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,903,503 - 31,906,010 (+)NCBINCBI36hg18NCBI36
Build 34631,903,502 - 31,906,010NCBI
Celera633,393,763 - 33,396,281 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,582,004 - 31,584,555 (+)NCBIHuRef
CHM1_1631,797,655 - 31,800,174 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HSPA1B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736398
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.