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Gene: Arg1 (arginase, liver) Mus musculus
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Symbol: Arg1
Name: arginase, liver
Description: Exhibits arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Predicted to localize to several cellular components, including the extracellular space; mitochondrial outer membrane; and neuronal cell body. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human ARG1 (arginase 1); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrabromodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI; AI256583; Arg-1; arginase 1, liver; arginase I; arginase-1; liver-type arginase; PGIF; type I arginase
Orthologs:
Homo sapiens (human) : ARG1 (arginase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Arg1 (arginase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arg1 (arginase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ARG1 (arginase 1)
Canis lupus familiaris (dog) : ARG1 (arginase 1)
Sus scrofa (pig) : ARG1 (arginase 1)
Chlorocebus sabaeus (green monkey) : ARG1 (arginase 1)
Heterocephalus glaber (naked mole-rat) : Arg1 (arginase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1024,915,221 - 24,927,484 (-)Ensembl
GRCm381024,915,207 - 24,927,470 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371024,635,013 - 24,647,276 (-)NCBIGRCm37mm9NCBIm37
MGSCv361024,604,637 - 24,617,896 (-)NCBImm8
Celera1025,846,180 - 25,858,528 (-)NCBICelera
Cytogenetic Map10A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Arg1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736430
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.