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Gene: ALOX5AP (arachidonate 5-lipoxygenase activating protein) Homo sapiens
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Symbol: ALOX5AP
Name: arachidonate 5-lipoxygenase activating protein
Description: Exhibits arachidonic acid binding activity and protein N-terminus binding activity. Involved in cellular response to calcium ion; leukotriene biosynthetic process; and protein homotrimerization. Localizes to the endoplasmic reticulum and nuclear membrane. Implicated in several diseases, including asthma; brain infarction (multiple); breast cancer; cerebral palsy; and coronary artery disease (multiple). Biomarker of artery disease (multiple); asthma; common cold; neuroblastoma; and obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLAP; MK-886-binding protein
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,713,478 - 30,764,428 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371331,287,615 - 31,338,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361330,207,669 - 30,236,556 (+)NCBINCBI36hg18NCBI36
Build 341330,207,668 - 30,236,556NCBI
Celera1312,378,644 - 12,407,516 (+)NCBI
Cytogenetic Map13q12.3NCBI
HuRef1312,105,618 - 12,156,585 (+)NCBIHuRef
CHM1_11331,255,200 - 31,306,135 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ALOX5AP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736460
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.