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Gene: PLAT (plasminogen activator, tissue type) Homo sapiens
Symbol: PLAT
Name: plasminogen activator, tissue type
Description: Exhibits phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in negative regulation of proteolysis and plasminogen activation. Localizes to the cell surface and cytoplasm. Implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and von Willebrand's disease 1. Biomarker of several diseases, including Henoch-Schoenlein purpura; acute promyelocytic leukemia; autoimmune thrombocytopenic purpura; blood coagulation disease (multiple); and diabetes mellitus (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alteplase; DKFZp686I03148; plasminogen/activator kringle; reteplase; T-PA; t-plasminogen activator; tissue plasminogen activator (t-PA); tissue-type plasminogen activator; TPA
Mus musculus (house mouse) : Plat (plasminogen activator, tissue)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plat (plasminogen activator, tissue type)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plat (plasminogen activator, tissue type)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAT (plasminogen activator, tissue type)
Canis lupus familiaris (dog) : PLAT (plasminogen activator, tissue type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plat (plasminogen activator, tissue type)
Sus scrofa (pig) : PLAT (plasminogen activator, tissue type)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38842,174,718 - 42,207,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,032,236 - 42,065,242 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,151,393 - 42,184,351 (-)NCBINCBI36hg18NCBI36
Build 34842,151,911 - 42,184,351NCBI
Celera840,981,190 - 41,014,147 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,559,713 - 40,592,984 (-)NCBIHuRef
CHM1_1842,080,535 - 42,113,859 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PLAT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736468
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.