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Gene: PLAT (plasminogen activator, tissue type) Homo sapiens
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Symbol: PLAT
Name: plasminogen activator, tissue type
Description: Exhibits phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in negative regulation of proteolysis and plasminogen activation. Localizes to the cell surface and cytoplasm. Implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and von Willebrand's disease 1. Biomarker of several diseases, including Henoch-Schoenlein purpura; acute promyelocytic leukemia; autoimmune thrombocytopenic purpura; blood coagulation disease (multiple); and diabetes mellitus (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alteplase; DKFZp686I03148; plasminogen/activator kringle; reteplase; T-PA; t-plasminogen activator; tissue plasminogen activator (t-PA); tissue-type plasminogen activator; TPA
Orthologs:
Mus musculus (house mouse) : Plat (plasminogen activator, tissue)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plat (plasminogen activator, tissue type)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plat (plasminogen activator, tissue type)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAT (plasminogen activator, tissue type)
Canis lupus familiaris (dog) : PLAT (plasminogen activator, tissue type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plat (plasminogen activator, tissue type)
Sus scrofa (pig) : PLAT (plasminogen activator, tissue type)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,174,718 - 42,207,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,032,236 - 42,065,242 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,151,393 - 42,184,351 (-)NCBINCBI36hg18NCBI36
Build 34842,151,911 - 42,184,351NCBI
Celera840,981,190 - 41,014,147 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,559,713 - 40,592,984 (-)NCBIHuRef
CHM1_1842,080,535 - 42,113,859 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PLAT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736468
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.