Gene: PLAT (plasminogen activator, tissue type) Homo sapiens
Analyze
Symbol:
PLAT
Name:
plasminogen activator, tissue type
Description:
Exhibits phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in negative regulation of proteolysis and plasminogen activation. Localizes to the cell surface and cytoplasm. Implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and von Willebrand's disease 1. Biomarker of several diseases, including Henoch-Schoenlein purpura; acute promyelocytic leukemia; autoimmune thrombocytopenic purpura; blood coagulation disease (multiple); and diabetes mellitus (multiple).
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
alteplase; DKFZp686I03148; plasminogen/activator kringle; reteplase; T-PA; t-plasminogen activator; tissue plasminogen activator (t-PA); tissue-type plasminogen activator; TPA
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Plat (plasminogen activator, tissue) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Plat (plasminogen activator, tissue type) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Plat (plasminogen activator, tissue type) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
PLAT (plasminogen activator, tissue type) NCBI
Ortholog
Canis lupus familiaris (dog):
PLAT (plasminogen activator, tissue type) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Plat (plasminogen activator, tissue type) NCBI
Ortholog
Sus scrofa (pig):
PLAT (plasminogen activator, tissue type) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Other homologs 2
Rattus norvegicus (Norway rat):
LOC100910418 (tissue-type plasminogen activator-like) HGNC
Ensembl
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Plat (plasminogen activator, tissue type)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Plat (plasminogen activator, tissue)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
plat (plasminogen activator, tissue)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
svh-1
Alliance
DIOPT (Ensembl Compara, PhylomeDB)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 8 42,174,718 - 42,207,565 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 8 42,032,236 - 42,065,242 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 8 42,151,393 - 42,184,351 (-) NCBI NCBI36 hg18 NCBI36 Build 34 8 42,151,911 - 42,184,351 NCBI Celera 8 40,981,190 - 41,014,147 (-) NCBI Cytogenetic Map 8 p11.21 NCBI HuRef 8 40,559,713 - 40,592,984 (-) NCBI HuRef CHM1_1 8 42,080,535 - 42,113,859 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
CRRD Manual Annotations
acute kidney failure IEP 11541071 protein:increased expression:plasma (human) RGD acute promyelocytic leukemia IEP 11541060 protein:increased expression:leukocyte (human) RGD Acute Traumatic Coagulopathy ISO RGD:3342 11554180 protein:increased expression:serum (rat) RGD Acute Traumatic Coagulopathy treatment ISO RGD:3342 11554179 RGD antiphospholipid syndrome IDA 1580877 RGD Arterial Thrombosis IDA 11541057 associated with Antiphospholipid Syndrome RGD Arterial Thrombosis treatment IDA 11541078 RGD autoimmune thrombocytopenic purpura IEP 11541072 protein:increased expression:plasma (human) RGD blood coagulation disease IEP 11541080 protein:increased expression:plasma (human) RGD brain edema ISO RGD:3342 6483826 associated with Burns, mRNA:increased expression:brain RGD brain ischemia no_association IAGP 1580879 DNA:polymorphism:-7351C>T (human) RGD Burns IEP 11541048 protein:increased expression:plasma (human) RGD Carotid Artery Injuries ISO RGD:3342 11537479 mRNA, protein:increased expression, increased activity:carotid artery (rat) RGD Central Nervous System Viral Diseases ISO RGD:3342 11537478 protein:increased expression:cerebellum (rat) RGD Cerebral Hemorrhage treatment ISO RGD:3342 11537477 human protein in a rat model RGD Cerebral Hemorrhage severity ISO RGD:732079 11541064 associated with Brain Injuries RGD Chronic Hepatitis IEP 11541068 protein:increased expression:plasma (human) RGD diabetic angiopathy IDA 2311663 associated with Diabetes Mellitus, Non-Insulin-Dependent RGD Diabetic Foot IDA 2311669 RGD Diabetic Nephropathies IEP 2311671 associated with Diabetes Mellitus, Non-Insulin-Dependent RGD diabetic neuropathy IEP 2311667 RGD disseminated intravascular coagulation treatment ISO RGD:3342 11541087 associated with Jaundice, Obstructive RGD disseminated intravascular coagulation IEP 11541052 protein:increased expression:plasma (human) RGD Endotoxemia treatment IDA 11541073 RGD Experimental Liver Cirrhosis ISO RGD:3342 6484134 RGD factor VIII deficiency treatment IDA 11552591 RGD Femur Head Necrosis IAGP 11541046 DNA:insertion:intron:IVS8 (human) RGD gestational diabetes IEP 2311668 RGD hemolytic-uremic syndrome IEP 11541069 associated with Escherichia coli Infections, protein:increased expression:plasma (human) RGD Henoch-Schoenlein purpura IEP 11541055 protein:increased expression:plasma (human) RGD Hypoxia-Ischemia, Brain onset ISO RGD:3342 6483831 RGD leukopenia IEP 11552575 associated with Sepsis, protein:decreased expression:plasma (human) RGD Metabolic Syndrome IEP 2311664 protein:increased expression:serum RGD middle cerebral artery infarction ISO RGD:3342 1580876 RGD Multiple Organ Failure ISO RGD:3342 11081009 protein:increased expression:plasma (rat) RGD myocardial infarction treatment IDA 11541077 RGD myocardial infarction IAGP 1580881 DNA:snp:enhancer:g.-7351C>T (human) RGD Noonan syndrome IEP 13207331 protein:increased activity:blood: RGD obesity IEP 2311677 RGD pancreatic adenocarcinoma IEP 11541045 mRNA:increased expression:pancreas (human) RGD peritonitis IDA 6484139 RGD Reperfusion Injury ISO RGD:3342 2311674 RGD Right Ventricular Hypertrophy ISO RGD:3342 11080746 protein:increased expression:heart right ventricle, heart left ventricle (rat) RGD sciatic neuropathy ISO RGD:3342 6483827 RGD Sepsis treatment ISO RGD:3342 1598921 RGD status epilepticus ISO RGD:3342 6484215 RGD Stroke IDA 9698433 RGD Stroke IEP 2311666 RGD transient cerebral ischemia ISO RGD:3342 1580875 Protein:increased expression, increased activity:hippocampus (rat) RGD Transplant Rejection susceptibility IEP 11541079 protein:increased expression:plasma (human) RGD type 1 diabetes mellitus IEP 2311676 RGD type 2 diabetes mellitus ISO RGD:3342 2311675 mRNA:decreased expression:kidney RGD type 2 diabetes mellitus ISO RGD:3342 1598920 protein:decreased expression:plasma (rat) RGD type 2 diabetes mellitus IDA 2311670 RGD type 2 diabetes mellitus IEP 2311665 RGD type 2 diabetes mellitus IDA 2311673 associated with Obesity RGD type 2 diabetes mellitus ISO RGD:732079 2311672 RGD von Willebrand's disease 1 treatment IDA 11552591 RGD Wounds and Injuries ISO RGD:3342 11541076 protein:increased expression:plasma (rat) RGD
Imported Annotations - ClinVar
Venous Thrombosis IAGP RGD:14975979 8554872 ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 Venous Thrombosis IAGP RGD:14975528 8554872 ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868
Imported Annotations - CTD
Airway Obstruction EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:25331496 allergic contact dermatitis EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17374397 amphetamine abuse EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15659235 angioedema EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16184341 more ... aphasia EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:12690208 Arterial Occlusive Diseases EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:15557913 atherosclerosis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:12677255 Back Pain EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12227717 Bacteremia EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:1430592 brain infarction EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:16190367 brain ischemia EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:7477192 more ... cardiac tamponade EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9633741 Cardiogenic Shock EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:1430592 Cerebral Hemorrhage EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:1430592 more ... cerebral infarction EXP 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:1579960 more ... Chemical and Drug Induced Liver Injury EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22507835 cholesterol embolism EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7939511 congestive heart failure EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22352330 coronary thrombosis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:1452937 more ... Embolism EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:16148626 Embolism and Thrombosis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:9684808 Experimental Liver Cirrhosis EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25380136 Hematoma, Epidural, Spinal EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10914357 , PMID:12227717 Hematoma, Subdural EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:1899364 Hemorrhage EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2514002 more ... hypertension EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22352330 Hypotension EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:1492007 Hypoxia EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:25331496 Intracranial Embolism and Thrombosis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:7482654 , PMID:8427107 Intracranial Hemorrhages EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2104561 more ... intracranial thrombosis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:8678742 intracranial vasospasm EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:19057314 lactic acidosis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:25331496 Low Back Pain EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:7888893 meningoencephalitis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:1430592 middle cerebral artery infarction EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:12297567 more ... myocardial infarction EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:1430592 more ... Nerve Degeneration EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19911010 Paresis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:12690208 pericardial effusion EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9633741 pulmonary embolism EXP 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:1899825 more ... Reperfusion Injury EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:9472885 respiratory failure EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:25331496 Spinal Cord Compression EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12227717 Stroke EXP 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:1598096 more ... Thromboembolism EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:8451030 thrombosis EXP 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:2123154 more ... toxic encephalopathy EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19442825 Venous Thromboembolism EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16167916 Venous Thrombosis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:11144008 more ... Ventricular Dysfunction, Left EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:8763515 Imported Annotations - OMIM
Thrombophilia, Familial, due to Decreased Release of Tissue Plasminogen Activator IAGP 7240710 OMIM
(+)-catechin increases expression EXP 6480464 Catechin results in increased expression of PLAT mRNA, Catechin results in increased expression of PLAT protein CTD PMID:11236827 (+)-catechin multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAT mRNA] CTD PMID:11236827 (+)-catechin increases expression ISO RGD:3342 6480464 Catechin results in increased expression of PLAT mRNA CTD PMID:17478321 (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of PLAT mRNA CTD PMID:12628509 (R)-mevalonic acid multiple interactions ISO RGD:3342 6480464 Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein] CTD PMID:10412747 (R)-mevalonic acid multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA], Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT] CTD PMID:12371961 , PMID:12753293 (S)-colchicine increases expression ISO RGD:3342 6480464 Colchicine results in increased expression of PLAT mRNA CTD PMID:20624997 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of PLAT mRNA, Nicotine results in increased expression of PLAT protein CTD PMID:11166759 , PMID:17151781 (S)-nicotine multiple interactions EXP 6480464 [Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of PLAT mRNA CTD PMID:18986645 (S)-nicotine affects expression EXP 6480464 Nicotine affects the expression of PLAT mRNA CTD PMID:18986645 1-chloro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrochlorobenzene results in increased expression of PLAT mRNA CTD PMID:17374397 1-naphthyl isothiocyanate increases expression ISO RGD:3342 6480464 1-Naphthylisothiocyanate results in increased expression of PLAT mRNA CTD PMID:25380136 , PMID:30723492 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PLAT protein more ... CTD PMID:12618251 more ... 17beta-estradiol multiple interactions EXP 6480464 2 more ... CTD PMID:17393018 more ... 17beta-estradiol increases expression ISO RGD:3342 6480464 Estradiol results in increased expression of PLAT mRNA CTD PMID:20838740 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of PLAT mRNA CTD PMID:15219790 more ... 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of PLAT mRNA CTD PMID:22574217 17beta-estradiol increases secretion EXP 6480464 Estradiol results in increased secretion of PLAT protein CTD PMID:3119194 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA, Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of PLAT protein] CTD PMID:19619570 , PMID:3119194 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732079 6480464 Tetrachlorodibenzodioxin results in increased expression of PLAT mRNA CTD PMID:27562557 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:732079 6480464 Tetrachlorodibenzodioxin results in decreased expression of PLAT mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:3342 6480464 Tetrachlorodibenzodioxin results in increased expression of PLAT mRNA, Tetrachlorodibenzodioxin results in increased expression of PLAT protein CTD PMID:11752688 , PMID:12128104 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:3342 6480464 CGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLAT protein] CTD PMID:12128104 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732079 6480464 [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA CTD PMID:21097750 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PLAT mRNA CTD PMID:19619570 2,3,7,8-Tetrachlorodibenzofuran multiple interactions EXP 6480464 2 more ... CTD PMID:3119194 2,6-di-tert-butyl-4-methylphenol multiple interactions EXP 6480464 Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein], Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein] CTD PMID:10856522 2-amino-2-deoxy-D-glucopyranose increases expression ISO RGD:732079 6480464 Glucosamine results in increased expression of PLAT mRNA CTD PMID:17178593 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO RGD:3342 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein] CTD PMID:10412747 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide multiple interactions ISO RGD:732079 6480464 Raclopride inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA] CTD PMID:15659235 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:732079 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLAT mRNA CTD PMID:16054899 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLAT mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane increases expression ISO RGD:3342 6480464 4, 4'-diaminodiphenylmethane results in increased expression of PLAT mRNA CTD PMID:25380136 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLAT mRNA CTD PMID:28628672 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression EXP 6480464 Oxazolone results in increased expression of PLAT mRNA CTD PMID:17374397 4-hydroxyphenyl retinamide increases expression ISO RGD:732079 6480464 Fenretinide results in increased expression of PLAT mRNA CTD PMID:28973697 5-fluorouracil increases expression EXP 6480464 Fluorouracil results in increased expression of PLAT mRNA CTD PMID:16101138 6-propyl-2-thiouracil increases expression ISO RGD:3342 6480464 Propylthiouracil results in increased expression of PLAT mRNA CTD PMID:24780913 8-bromo-3',5'-cyclic AMP increases expression EXP 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PLAT mRNA CTD PMID:20147733 9-cis-retinoic acid increases expression EXP 6480464 Alitretinoin results in increased expression of PLAT mRNA CTD PMID:15982314 actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAT mRNA] more ... CTD PMID:11236827 aflatoxin B1 increases expression ISO RGD:732079 6480464 Aflatoxin B1 results in increased expression of PLAT mRNA CTD PMID:19770486 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of PLAT mRNA CTD PMID:22100608 aldehydo-D-glucosamine increases expression ISO RGD:732079 6480464 Glucosamine results in increased expression of PLAT mRNA CTD PMID:17178593 aldehydo-D-glucose increases expression ISO RGD:732079 6480464 Glucose results in increased expression of PLAT mRNA CTD PMID:17178593 all-trans-4-oxoretinoic acid increases expression EXP 6480464 4-oxoretinoic acid results in increased expression of PLAT mRNA CTD PMID:15982314 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin metabolite results in increased expression of PLAT mRNA more ... CTD PMID:11775254 more ... all-trans-retinoic acid increases expression ISO RGD:3342 6480464 Tretinoin results in increased expression of PLAT mRNA CTD PMID:20488242 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of PLAT mRNA CTD PMID:21934132 all-trans-retinoic acid increases expression ISO RGD:732079 6480464 Tretinoin results in increased expression of PLAT mRNA CTD PMID:16604517 aminoguanidine multiple interactions EXP 6480464 pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein] CTD PMID:10856522 ammonium chloride affects expression ISO RGD:3342 6480464 Ammonium Chloride affects the expression of PLAT mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:3342 6480464 pyrazolanthrone inhibits the reaction [Valproic Acid results in increased activity of PLAT protein] CTD PMID:23378038 arsenite(3-) decreases expression EXP 6480464 arsenite results in decreased expression of PLAT mRNA CTD PMID:11864708 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PLAT mRNA CTD PMID:20458559 , PMID:22521957 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PLAT mRNA CTD PMID:20064835 , PMID:31255691 benzo[a]pyrene multiple interactions ISO RGD:732079 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PLAT mRNA CTD PMID:27858113 benzo[a]pyrene increases expression ISO RGD:732079 6480464 Benzo(a)pyrene results in increased expression of PLAT mRNA CTD PMID:21569818 benzo[a]pyrene decreases expression ISO RGD:732079 6480464 Benzo(a)pyrene results in decreased expression of PLAT mRNA CTD PMID:19770486 benzo[b]fluoranthene multiple interactions ISO RGD:732079 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PLAT mRNA CTD PMID:27858113 beta-carotene multiple interactions ISO RGD:732079 6480464 [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA CTD PMID:24657404 beta-D-glucosamine increases expression ISO RGD:732079 6480464 Glucosamine results in increased expression of PLAT mRNA CTD PMID:17178593 bexarotene increases expression EXP 6480464 bexarotene results in increased expression of PLAT mRNA CTD PMID:17178900 bis(2-chloroethyl) sulfide affects expression ISO RGD:3342 6480464 Mustard Gas affects the expression of PLAT mRNA CTD PMID:15651846 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PLAT mRNA CTD PMID:23019147 bisphenol A increases expression ISO RGD:732079 6480464 bisphenol A results in increased expression of PLAT mRNA CTD PMID:30951980 bisphenol A affects expression ISO RGD:3342 6480464 bisphenol A affects the expression of PLAT mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:732079 6480464 bisphenol A results in decreased expression of PLAT mRNA CTD PMID:26063408 bucladesine multiple interactions EXP 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PLAT mRNA CTD PMID:20823114 butan-1-ol multiple interactions EXP 6480464 [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of PLAT mRNA CTD PMID:29432896 butanal increases expression EXP 6480464 butyraldehyde results in increased expression of PLAT mRNA CTD PMID:26079696 butyric acid increases activity ISO RGD:3342 6480464 Butyric Acid results in increased activity of PLAT protein CTD PMID:23378038 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of PLAT mRNA CTD PMID:21694771 cadmium dichloride affects expression ISO RGD:3342 6480464 Cadmium Chloride affects the expression of PLAT mRNA CTD PMID:22110744 cadmium dichloride decreases methylation ISO RGD:3342 6480464 Cadmium Chloride results in decreased methylation of PLAT promoter CTD PMID:22457795 calciol increases expression ISO RGD:732079 6480464 Cholecalciferol results in increased expression of PLAT mRNA CTD PMID:17170073 carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of PLAT mRNA CTD PMID:25979313 carbon nanotube affects expression EXP 6480464 Nanotubes, Carbon affects the expression of PLAT mRNA CTD PMID:25790727 carbon nanotube increases expression ISO RGD:732079 6480464 Nanotubes, Carbon analog results in increased expression of PLAT mRNA, Nanotubes, Carbon results in increased expression of PLAT mRNA CTD PMID:25554681 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon results in decreased expression of PLAT protein CTD PMID:25790727 carbon nanotube multiple interactions EXP 6480464 [Nanotubes, Carbon co-treated with 6-hydroxy-2 more ... CTD PMID:25790727 chloroprene increases expression ISO RGD:732079 6480464 Chloroprene results in increased expression of PLAT mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:732079 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAT mRNA CTD PMID:20938992 chromium(6+) affects expression ISO RGD:732079 6480464 chromium hexavalent ion affects the expression of PLAT mRNA CTD PMID:28472532 chrysene multiple interactions ISO RGD:732079 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PLAT mRNA CTD PMID:27858113 cisplatin increases expression ISO RGD:732079 6480464 Cisplatin results in increased expression of PLAT mRNA CTD PMID:21151649 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of PLAT mRNA CTD PMID:27392435 cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of PLAT mRNA CTD PMID:27392435 copper atom multiple interactions EXP 6480464 [Copper results in increased oxidation of LPA protein] which results in decreased secretion of PLAT protein CTD PMID:11681624 copper atom increases expression ISO RGD:3342 6480464 Copper results in increased expression of PLAT mRNA CTD PMID:30556269 copper(0) multiple interactions EXP 6480464 [Copper results in increased oxidation of LPA protein] which results in decreased secretion of PLAT protein CTD PMID:11681624 copper(0) increases expression ISO RGD:3342 6480464 Copper results in increased expression of PLAT mRNA CTD PMID:30556269 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of PLAT mRNA CTD PMID:19549813 cycloheximide multiple interactions ISO RGD:3342 6480464 Cycloheximide promotes the reaction [Isoproterenol results in increased expression of PLAT mRNA] CTD PMID:2477232 cyclosporin A increases expression ISO RGD:732079 6480464 Cyclosporine results in increased expression of PLAT mRNA CTD PMID:15339989 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of PLAT mRNA CTD PMID:19159671 , PMID:22147139 cytarabine decreases expression EXP 6480464 Cytarabine results in decreased expression of PLAT mRNA CTD PMID:21198554 cytochalasin D increases expression EXP 6480464 Cytochalasin D results in increased expression of PLAT CTD PMID:12371961 D-glucose increases expression ISO RGD:732079 6480464 Glucose results in increased expression of PLAT mRNA CTD PMID:17178593 daunorubicin multiple interactions EXP 6480464 [Daunorubicin results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 DDT decreases expression EXP 6480464 DDT results in decreased expression of PLAT mRNA CTD PMID:25014179 dexamethasone multiple interactions ISO RGD:732079 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLAT mRNA CTD PMID:16054899 dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLAT mRNA CTD PMID:28628672 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of PLAT mRNA CTD PMID:25047013 dexamethasone decreases activity ISO RGD:3342 6480464 Dexamethasone results in decreased activity of PLAT protein CTD PMID:3127913 dexamethasone multiple interactions ISO RGD:3342 6480464 Dexamethasone inhibits the reaction [IL1B protein results in increased activity of PLAT protein] more ... CTD PMID:15963473 dexamethasone decreases activity EXP 6480464 Dexamethasone results in decreased activity of PLAT protein CTD PMID:1656149 dextran sulfate multiple interactions ISO RGD:732079 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PLAT mRNA CTD PMID:29950665 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PLAT mRNA CTD PMID:20458559 , PMID:22521957 dibenzo[a,l]pyrene decreases expression EXP 6480464 dibenzo(a, l)pyrene results in decreased expression of PLAT mRNA CTD PMID:31255691 dibutyl phthalate increases expression ISO RGD:3342 6480464 Dibutyl Phthalate results in increased expression of PLAT mRNA CTD PMID:21266533 dichlorine multiple interactions ISO RGD:3342 6480464 [Ozone co-treated with Chlorine] results in decreased expression of PLAT mRNA CTD PMID:18636392 dienogest multiple interactions EXP 6480464 [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PLAT protein CTD PMID:15288212 diethyl maleate decreases expression ISO RGD:732079 6480464 diethyl maleate results in decreased expression of PLAT mRNA CTD PMID:25270620 diethyl maleate increases expression ISO RGD:3342 6480464 diethyl maleate results in increased expression of PLAT mRNA CTD PMID:21161181 dioxygen multiple interactions ISO RGD:732079 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PLAT mRNA CTD PMID:30529165 dipyridamole multiple interactions EXP 6480464 KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein] CTD PMID:15733978 dipyridamole increases secretion EXP 6480464 Dipyridamole results in increased secretion of PLAT protein CTD PMID:15733978 diuron decreases expression ISO RGD:3342 6480464 Diuron results in decreased expression of PLAT mRNA CTD PMID:21551480 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 dorsomorphin multiple interactions ISO RGD:3342 6480464 dorsomorphin inhibits the reaction [Resveratrol results in decreased activity of PLAT protein] CTD PMID:24599349 doxorubicin affects expression EXP 6480464 Doxorubicin affects the expression of PLAT mRNA CTD PMID:29803840 edaravone multiple interactions ISO RGD:3342 6480464 Edaravone inhibits the reaction [PLAT protein results in increased activity of RELA protein] more ... CTD PMID:19095969 endosulfan increases activity ISO RGD:3342 6480464 Endosulfan results in increased activity of PLAT protein CTD PMID:21804306 endosulfan decreases expression ISO RGD:3342 6480464 Endosulfan results in decreased expression of PLAT mRNA CTD PMID:29391264 endosulfan multiple interactions ISO RGD:3342 6480464 [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Endosulfan results in increased activity of PLAT protein] CTD PMID:21804306 ethanol increases expression ISO RGD:3342 6480464 Ethanol results in increased expression of PLAT mRNA CTD PMID:17478321 ethanol multiple interactions EXP 6480464 [[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of PLAT mRNA CTD PMID:29432896 Ethyl icosapentate increases expression ISO RGD:3342 6480464 eicosapentaenoic acid ethyl ester results in increased expression of PLAT protein CTD PMID:14614217 ethylenediaminetetraacetic acid multiple interactions ISO RGD:732079 6480464 Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA] more ... CTD PMID:21615740 eugenol increases expression EXP 6480464 Eugenol results in increased expression of PLAT mRNA CTD PMID:17374397 fenbuconazole increases expression EXP 6480464 fenbuconazole results in increased expression of PLAT mRNA CTD PMID:15942997 folic acid multiple interactions ISO RGD:732079 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAT mRNA CTD PMID:20938992 furan increases expression ISO RGD:3342 6480464 furan results in increased expression of PLAT mRNA CTD PMID:27387713 genistein increases expression EXP 6480464 Genistein results in increased expression of PLAT mRNA CTD PMID:23019147 genistein increases expression ISO RGD:3342 6480464 Genistein results in increased expression of PLAT mRNA CTD PMID:20838740 geranylgeraniol multiple interactions EXP 6480464 geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA], geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT] CTD PMID:12371961 , PMID:12753293 gestodene multiple interactions EXP 6480464 [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PLAT protein, [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLAT protein CTD PMID:12618251 glucose increases expression ISO RGD:732079 6480464 Glucose results in increased expression of PLAT mRNA CTD PMID:17178593 Goe 6976 multiple interactions ISO RGD:732079 6480464 Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT mRNA], Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT protein] CTD PMID:21615740 GW 4064 multiple interactions ISO RGD:732079 6480464 GW 4064 promotes the reaction [NR1H4 protein binds to PLAT gene] CTD PMID:20091679 heparin increases expression ISO RGD:732079 6480464 Heparin results in increased expression of PLAT mRNA, Heparin results in increased expression of PLAT protein CTD PMID:14630814 , PMID:16190367 icatibant decreases expression EXP 6480464 icatibant results in decreased expression of PLAT protein CTD PMID:16321614 indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLAT mRNA CTD PMID:28628672 irinotecan increases expression ISO RGD:3342 6480464 Irinotecan results in increased expression of PLAT mRNA CTD PMID:20097248 irinotecan decreases expression EXP 6480464 Irinotecan analog results in decreased expression of PLAT mRNA CTD PMID:18927307 isobutanol multiple interactions EXP 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of PLAT mRNA CTD PMID:29432896 isoprenaline multiple interactions ISO RGD:3342 6480464 Cycloheximide promotes the reaction [Isoproterenol results in increased expression of PLAT mRNA] CTD PMID:2477232 isoprenaline increases secretion ISO RGD:3342 6480464 Isoproterenol results in increased secretion of PLAT protein CTD PMID:2477232 isoprenaline increases expression ISO RGD:3342 6480464 Isoproterenol results in increased expression of PLAT mRNA CTD PMID:2477232 isotretinoin increases expression EXP 6480464 Isotretinoin results in increased expression of PLAT mRNA CTD PMID:15982314 ketamine increases expression ISO RGD:3342 6480464 Ketamine results in increased expression of PLAT mRNA CTD PMID:20080153 KT 5823 multiple interactions EXP 6480464 KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein] CTD PMID:15733978 L-ascorbic acid multiple interactions ISO RGD:3342 6480464 [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Endosulfan results in increased activity of PLAT protein], Ascorbic Acid promotes the reaction [Vitamin E results in increased activity of PLAT protein] CTD PMID:21804306 L-methionine multiple interactions ISO RGD:732079 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAT mRNA CTD PMID:20938992 lead diacetate affects activity ISO RGD:3342 6480464 lead acetate affects the activity of PLAT protein CTD PMID:2143947 levonorgestrel multiple interactions EXP 6480464 [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of PLAT protein, [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased activity of PLAT protein CTD PMID:12618251 more ... lipopolysaccharide multiple interactions ISO RGD:732079 6480464 [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA CTD PMID:21097750 lipopolysaccharide increases expression ISO RGD:3342 6480464 Lipopolysaccharides results in increased expression of PLAT protein CTD PMID:27098997 lipopolysaccharide multiple interactions ISO RGD:3342 6480464 Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of PLAT protein] CTD PMID:27098997 losartan decreases expression ISO RGD:3342 6480464 Losartan results in decreased expression of PLAT mRNA CTD PMID:15100363 lovastatin multiple interactions ISO RGD:3342 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein], Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein] CTD PMID:10412747 lovastatin increases secretion ISO RGD:732079 6480464 Lovastatin results in increased secretion of PLAT protein CTD PMID:12405293 lovastatin increases expression ISO RGD:3342 6480464 Lovastatin results in increased expression of PLAT CTD PMID:10412747 malathion decreases expression EXP 6480464 Malathion results in decreased expression of PLAT mRNA CTD PMID:16079077 medroxyprogesterone acetate multiple interactions EXP 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PLAT mRNA CTD PMID:20823114 metformin increases activity EXP 6480464 Metformin results in increased activity of PLAT protein CTD PMID:1900072 methamphetamine increases expression ISO RGD:732079 6480464 Methamphetamine results in increased expression of PLAT mRNA CTD PMID:15659235 methamphetamine multiple interactions ISO RGD:3342 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of PLAT mRNA CTD PMID:19564919 methamphetamine increases expression ISO RGD:3342 6480464 Methamphetamine results in increased expression of PLAT mRNA CTD PMID:19564919 methamphetamine multiple interactions ISO RGD:732079 6480464 Raclopride inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA], SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA] CTD PMID:15659235 methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of PLAT mRNA CTD PMID:21678067 mifepristone increases expression EXP 6480464 Mifepristone results in increased expression of PLAT mRNA CTD PMID:17584828 mifepristone decreases expression ISO RGD:3342 6480464 Mifepristone results in decreased expression of PLAT mRNA CTD PMID:25972201 mifepristone multiple interactions ISO RGD:3342 6480464 Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]] CTD PMID:15963473 mitoxantrone affects response to substance EXP 6480464 PLAT protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 morphine affects response to substance ISO RGD:732079 6480464 PLAT protein affects the susceptibility to Morphine CTD PMID:16619846 N-acetylsphingosine multiple interactions EXP 6480464 [N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 N-nitrosodimethylamine increases expression ISO RGD:3342 6480464 Dimethylnitrosamine results in increased expression of PLAT mRNA CTD PMID:25380136 naphthalene increases expression ISO RGD:732079 6480464 naphthalene results in increased expression of PLAT mRNA CTD PMID:18978301 nickel sulfate increases expression ISO RGD:732079 6480464 nickel sulfate results in increased expression of PLAT mRNA CTD PMID:16100012 nickel sulfate increases expression EXP 6480464 nickel sulfate results in increased expression of PLAT mRNA CTD PMID:16780908 , PMID:17374397 nicotine increases expression EXP 6480464 Nicotine results in increased expression of PLAT mRNA, Nicotine results in increased expression of PLAT protein CTD PMID:11166759 , PMID:17151781 nicotine affects expression EXP 6480464 Nicotine affects the expression of PLAT mRNA CTD PMID:18986645 nicotine multiple interactions EXP 6480464 [Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of PLAT mRNA CTD PMID:18986645 nitric oxide multiple interactions ISO RGD:732079 6480464 PLAT protein affects the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:18195371 nitric oxide increases secretion ISO RGD:732079 6480464 PLAT protein results in increased secretion of Nitric Oxide CTD PMID:18195371 nonanedioic acid multiple interactions EXP 6480464 azelaic acid results in decreased expression of and results in decreased secretion of PLAT protein CTD PMID:8635147 nonanedioic acid decreases expression EXP 6480464 azelaic acid results in decreased expression of PLAT mRNA CTD PMID:8635147 norgestimate multiple interactions EXP 6480464 [Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of PLAT protein, [Ethinyl Estradiol co-treated with norgestimate] results in increased activity of PLAT protein CTD PMID:12618251 notoginsenoside R1 multiple interactions EXP 6480464 notoginsenoside R1 results in increased expression of [PLAT protein binds to SERPINE1 protein] CTD PMID:8018658 notoginsenoside R1 increases expression EXP 6480464 notoginsenoside R1 results in increased expression of PLAT mRNA, notoginsenoside R1 results in increased expression of PLAT protein CTD PMID:8018658 , PMID:9220151 oxaliplatin multiple interactions ISO RGD:3342 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PLAT mRNA CTD PMID:25729387 ozone multiple interactions ISO RGD:3342 6480464 [Ozone co-treated with Chlorine] results in decreased expression of PLAT mRNA CTD PMID:18636392 ozone increases expression ISO RGD:3342 6480464 Ozone results in increased expression of PLAT mRNA CTD PMID:20980218 panobinostat multiple interactions EXP 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA CTD PMID:27188386 panobinostat increases expression EXP 6480464 panobinostat results in increased expression of PLAT mRNA CTD PMID:26272509 paracetamol affects expression ISO RGD:732079 6480464 Acetaminophen affects the expression of PLAT mRNA CTD PMID:17562736 paracetamol increases response to substance ISO RGD:732079 6480464 PLAT protein results in increased susceptibility to Acetaminophen CTD PMID:22507835 pentanal increases expression EXP 6480464 pentanal results in increased expression of PLAT mRNA CTD PMID:26079696 pentane-2,3-dione increases expression ISO RGD:3342 6480464 2, 3-pentanedione results in increased expression of PLAT mRNA CTD PMID:25710175 perfluorooctanoic acid increases expression ISO RGD:732079 6480464 perfluorooctanoic acid results in increased expression of PLAT mRNA CTD PMID:30711707 phenobarbital multiple interactions ISO RGD:732079 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PLAT mRNA] CTD PMID:19482888 phenobarbital increases expression ISO RGD:732079 6480464 Phenobarbital results in increased expression of PLAT mRNA CTD PMID:19482888 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate increases secretion EXP 6480464 Tetradecanoylphorbol Acetate results in increased secretion of PLAT protein CTD PMID:3119194 phorbol 13-acetate 12-myristate increases expression EXP 6480464 Tetradecanoylphorbol Acetate results in increased expression of PLAT protein CTD PMID:8018658 pirinixic acid multiple interactions ISO RGD:732079 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PLAT mRNA, [pirinixic acid co-treated with PPARA] results in increased expression of PLAT mRNA CTD PMID:19710929 , PMID:20813756 pirinixic acid increases expression ISO RGD:732079 6480464 pirinixic acid results in increased expression of PLAT mRNA CTD PMID:20813756 piroxicam decreases expression EXP 6480464 Piroxicam results in decreased expression of PLAT mRNA CTD PMID:21858171 potassium chromate increases expression EXP 6480464 potassium chromate(VI) results in increased expression of PLAT mRNA CTD PMID:22714537 prednisone increases expression EXP 6480464 Prednisone results in increased expression of PLAT protein CTD PMID:10452346 procymidone decreases expression ISO RGD:3342 6480464 procymidone results in decreased expression of PLAT mRNA CTD PMID:15686871 progesterone increases expression EXP 6480464 Progesterone results in increased expression of PLAT mRNA CTD PMID:21795739 progesterone decreases expression ISO RGD:732079 6480464 Progesterone results in decreased expression of PLAT mRNA CTD PMID:22238285 propanal increases expression EXP 6480464 propionaldehyde results in increased expression of PLAT mRNA CTD PMID:26079696 protoporphyrin decreases expression EXP 6480464 protoporphyrin IX results in decreased expression of PLAT protein CTD PMID:23624237 quercetin multiple interactions EXP 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]] more ... CTD PMID:11236827 , PMID:18419748 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of PLAT mRNA CTD PMID:21632981 quercetin increases expression ISO RGD:3342 6480464 Quercetin results in increased expression of PLAT mRNA CTD PMID:17478321 , PMID:18095365 quercetin increases secretion EXP 6480464 Quercetin results in increased secretion of PLAT protein CTD PMID:18419748 quercetin increases expression EXP 6480464 Quercetin results in increased expression of PLAT mRNA, Quercetin results in increased expression of PLAT protein CTD PMID:11236827 , PMID:18419748 raloxifene increases expression EXP 6480464 Raloxifene Hydrochloride results in increased expression of PLAT protein CTD PMID:16167916 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of PLAT mRNA, resveratrol results in increased expression of PLAT protein CTD PMID:11236827 resveratrol multiple interactions ISO RGD:3342 6480464 dorsomorphin inhibits the reaction [Resveratrol results in decreased activity of PLAT protein], Resveratrol results in decreased expression of and results in decreased activity of PLAT protein CTD PMID:24599349 resveratrol multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [resveratrol results in increased expression of PLAT mRNA] CTD PMID:11236827 rifampicin decreases expression EXP 6480464 Rifampin results in decreased expression of PLAT mRNA CTD PMID:24552687 Ro 41-5253 multiple interactions EXP 6480464 Ro 41-5253 inhibits the reaction [Retinoids results in increased expression of PLAT] CTD PMID:7556191 rofecoxib increases expression EXP 6480464 rofecoxib results in increased expression of PLAT mRNA CTD PMID:16580899 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 SCH 23390 multiple interactions ISO RGD:732079 6480464 SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA] CTD PMID:15659235 SCH 23390 multiple interactions ISO RGD:3342 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of PLAT mRNA CTD PMID:19564919 silicon dioxide increases expression EXP 6480464 Silicon Dioxide analog results in increased expression of PLAT mRNA CTD PMID:25895662 simvastatin increases activity EXP 6480464 Simvastatin results in increased activity of PLAT protein CTD PMID:12371961 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of PLAT more ... CTD PMID:12371961 , PMID:12753293 simvastatin multiple interactions EXP 6480464 geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA] more ... CTD PMID:12371961 , PMID:12753293 simvastatin decreases expression ISO RGD:3342 6480464 Simvastatin results in decreased expression of PLAT mRNA CTD PMID:16414398 sodium arsenite decreases expression ISO RGD:732079 6480464 sodium arsenite results in decreased expression of PLAT mRNA CTD PMID:25270620 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of PLAT mRNA CTD PMID:29301061 sodium arsenite increases expression ISO RGD:732079 6480464 sodium arsenite results in increased expression of PLAT mRNA CTD PMID:16014739 Soman increases expression ISO RGD:3342 6480464 Soman results in increased expression of PLAT mRNA CTD PMID:19281266 sotalol increases expression ISO RGD:3342 6480464 Sotalol results in increased expression of PLAT protein CTD PMID:9594410 spironolactone increases expression EXP 6480464 Spironolactone results in increased expression of PLAT protein CTD PMID:12424430 sulindac multiple interactions EXP 6480464 [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of PLAT mRNA CTD PMID:12628509 tacrolimus hydrate decreases expression ISO RGD:732079 6480464 Tacrolimus results in decreased expression of PLAT mRNA CTD PMID:25270620 tetrachloromethane multiple interactions ISO RGD:732079 6480464 [Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of PLAT mRNA more ... CTD PMID:17944888 more ... tetrachloromethane increases expression ISO RGD:732079 6480464 Carbon Tetrachloride results in increased expression of PLAT mRNA CTD PMID:25827057 tetraethyllead affects activity ISO RGD:3342 6480464 Tetraethyl Lead affects the activity of PLAT protein CTD PMID:2143947 tetraphene multiple interactions ISO RGD:732079 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PLAT mRNA CTD PMID:27858113 titanium dioxide increases expression ISO RGD:732079 6480464 titanium dioxide results in increased expression of PLAT mRNA, titanium dioxide results in increased expression of PLAT protein CTD PMID:23565150 , PMID:27760801 titanium dioxide multiple interactions ISO RGD:732079 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PLAT mRNA CTD PMID:29950665 titanium dioxide decreases expression ISO RGD:3342 6480464 titanium dioxide results in decreased expression of PLAT mRNA CTD PMID:30012374 toluene increases expression ISO RGD:3342 6480464 Toluene results in increased expression of PLAT mRNA CTD PMID:22967744 topotecan multiple interactions ISO RGD:3342 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PLAT mRNA CTD PMID:25729387 Trapidil multiple interactions ISO RGD:3342 6480464 Trapidil affects the reaction [PTH protein affects the expression of PLAT mRNA] CTD PMID:18635661 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of PLAT mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA CTD PMID:27188386 triclosan increases expression EXP 6480464 Triclosan results in increased expression of PLAT mRNA CTD PMID:30510588 urethane decreases expression EXP 6480464 Urethane results in decreased expression of PLAT mRNA CTD PMID:28818685 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of PLAT mRNA CTD PMID:24383497 more ... valproic acid increases activity ISO RGD:3342 6480464 Valproic Acid results in increased activity of PLAT protein CTD PMID:23378038 valproic acid decreases response to substance ISO RGD:3342 6480464 PLAT protein mutant form results in decreased susceptibility to Valproic Acid CTD PMID:23378038 valproic acid multiple interactions ISO RGD:3342 6480464 [Valproic Acid results in decreased activity of SERPINE1 protein] which results in increased activity of PLAT protein more ... CTD PMID:23378038 valproic acid decreases response to substance ISO RGD:732079 6480464 PLAT gene mutant form results in decreased susceptibility to Valproic Acid CTD PMID:23378038 valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA CTD PMID:27188386 vincaleukoblastine increases expression ISO RGD:3342 6480464 Vinblastine results in increased expression of PLAT mRNA CTD PMID:20624997 vinclozolin decreases expression ISO RGD:3342 6480464 vinclozolin results in decreased expression of PLAT mRNA CTD PMID:15686871 vincristine increases expression ISO RGD:3342 6480464 Vincristine results in increased expression of PLAT mRNA CTD PMID:20624997 vitamin E increases activity ISO RGD:3342 6480464 Vitamin E results in increased activity of PLAT protein CTD PMID:21804306 vitamin E multiple interactions ISO RGD:3342 6480464 [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Endosulfan results in increased activity of PLAT protein], Ascorbic Acid promotes the reaction [Vitamin E results in increased activity of PLAT protein] CTD PMID:21804306 vorinostat multiple interactions EXP 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA CTD PMID:27188386 vorinostat increases expression EXP 6480464 vorinostat results in increased expression of PLAT mRNA CTD PMID:26272509 zinc atom multiple interactions ISO RGD:732079 6480464 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA] more ... CTD PMID:21615740 zinc atom multiple interactions ISO RGD:3342 6480464 Zinc inhibits the reaction [Zinc deficiency results in increased expression of PLAT mRNA] CTD PMID:19111725 zinc atom increases expression ISO RGD:3342 6480464 Zinc deficiency results in increased expression of PLAT mRNA CTD PMID:19111725 zinc atom increases secretion ISO RGD:732079 6480464 Zinc results in increased secretion of PLAT protein CTD PMID:21615740 zinc atom increases expression ISO RGD:732079 6480464 Zinc results in increased expression of PLAT mRNA CTD PMID:21615740 zinc(0) multiple interactions ISO RGD:732079 6480464 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA] more ... CTD PMID:21615740 zinc(0) increases expression ISO RGD:732079 6480464 Zinc results in increased expression of PLAT mRNA CTD PMID:21615740 zinc(0) increases secretion ISO RGD:732079 6480464 Zinc results in increased secretion of PLAT protein CTD PMID:21615740 zinc(0) increases expression ISO RGD:3342 6480464 Zinc deficiency results in increased expression of PLAT mRNA CTD PMID:19111725 zinc(0) multiple interactions ISO RGD:3342 6480464 Zinc inhibits the reaction [Zinc deficiency results in increased expression of PLAT mRNA] CTD PMID:19111725 zoledronic acid increases expression EXP 6480464 zoledronic acid results in increased expression of PLAT mRNA CTD PMID:24714768
Gene-Chemical Interaction Annotations
