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Gene: PTN (pleiotrophin) Homo sapiens
Symbol: PTN
Name: pleiotrophin
Description: The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF; HBNF-1; heparin affin regulatory protein; heparin binding growth factor 8; heparin-binding brain mitogen; heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; heparin-binding neurite outgrowth-promoting factor 1; NEGF1; neurite growth-promoting factor 1; OSF-1; osteoblast-specific factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
Mus musculus (house mouse) : Ptn (pleiotrophin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptn (pleiotrophin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptn (pleiotrophin)
Pan paniscus (bonobo/pygmy chimpanzee) : PTN (pleiotrophin)
Canis lupus familiaris (dog) : PTN (pleiotrophin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptn (pleiotrophin)
Sus scrofa (pig) : PTN (pleiotrophin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387137,227,341 - 137,343,990 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377136,912,088 - 137,028,606 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367136,562,628 - 136,679,086 (-)NCBINCBI36hg18NCBI36
Build 347136,369,349 - 136,485,801NCBI
Celera7131,651,010 - 131,767,463 (-)NCBI
Cytogenetic Map7q33NCBI
HuRef7131,217,379 - 131,333,760 (-)NCBIHuRef
CHM1_17136,845,103 - 136,961,928 (-)NCBICHM1_1
CRA_TCAGchr7v27136,256,123 - 136,372,579 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PTN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736479
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.