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Gene: SQSTM1 (sequestosome 1) Homo sapiens
Symbol: SQSTM1
Name: sequestosome 1
Description: Exhibits several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; SH2 domain binding activity; and enzyme binding activity. Involved in several processes, including protein localization to perinuclear region of cytoplasm; regulation of protein complex stability; and selective autophagy. Localizes to several cellular components, including P-body; PML body; and autophagosome. Implicated in FTDALS3 and Paget's disease of bone.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A170; autophagy receptor p62; DMRV; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; FTDALS3; NADGP; OSIL; oxidative stress induced like; p60; p62; p62B; PDB3; phosphotyrosine independent ligand for the Lck SH2 domain p62; phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; sequestosome-1; ubiquitin-binding protein p62; ZIP3
Mus musculus (house mouse) : Sqstm1 (sequestosome 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sqstm1 (sequestosome 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sqstm1 (sequestosome 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SQSTM1 (sequestosome 1)
Canis lupus familiaris (dog) : SQSTM1 (sequestosome 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sqstm1 (sequestosome 1)
Sus scrofa (pig) : SQSTM1 (sequestosome 1)
Chlorocebus sabaeus (African green monkey) : SQSTM1 (sequestosome 1)
Heterocephalus glaber (naked mole-rat) : Sqstm1 (sequestosome 1)
more info ...
Related Pseudogenes: SQSTM1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5179,806,398 - 179,838,078 (+)EnsemblGRCh38hg38GRCh38
GRCh385179,806,393 - 179,838,078 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375179,233,388 - 179,265,078 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,180,503 - 179,197,684 (+)NCBINCBI36hg18NCBI36
Build 345179,180,502 - 179,197,681NCBI
Celera5174,858,545 - 174,890,234 (+)NCBI
Cytogenetic Map5q35.3NCBI
HuRef5173,959,564 - 173,990,246 (+)NCBIHuRef
CHM1_15178,665,789 - 178,697,494 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants