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Gene: Sqstm1 (sequestosome 1) Mus musculus
Symbol: Sqstm1
Name: sequestosome 1
Description: Exhibits K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of long-term synaptic potentiation; and positive regulation of protein localization to plasma membrane. Localizes to several cellular components, including the aggresome; autolysosome; and sperm midpiece. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in FTDALS3 and Paget's disease of bone. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human SQSTM1 (sequestosome 1); PARTICIPATES IN interleukin-1 signaling pathway; mitochondrial autophagy pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A170; OSF-6; Osi; oxidative stress induced; p62; sequestosome-1; STAP; STONE14; ubiquitin-binding protein p62
Homo sapiens (human) : SQSTM1 (sequestosome 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sqstm1 (sequestosome 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sqstm1 (sequestosome 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SQSTM1 (sequestosome 1)
Canis lupus familiaris (dog) : SQSTM1 (sequestosome 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sqstm1 (sequestosome 1)
Sus scrofa (pig) : SQSTM1 (sequestosome 1)
Chlorocebus sabaeus (African green monkey) : SQSTM1 (sequestosome 1)
Heterocephalus glaber (naked mole-rat) : Sqstm1 (sequestosome 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1150,199,366 - 50,210,827 (-)Ensembl
GRCm381150,200,152 - 50,210,820 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371150,013,654 - 50,024,292 (-)NCBIGRCm37mm9NCBIm37
MGSCv361150,043,575 - 50,054,213 (-)NCBImm8
Celera1154,760,561 - 54,771,229 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sqstm1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736485
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.