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Gene: UNC5B (unc-5 netrin receptor B) Homo sapiens
Symbol: UNC5B
Name: unc-5 netrin receptor B
Description: Predicted to have netrin receptor activity. Involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and positive regulation of phosphatidylinositol 3-kinase signaling. Predicted to localize to the integral component of membrane; membrane raft; and plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: netrin receptor UNC5B; p53-regulated receptor for death and life protein 1; p53RDL1; transmembrane receptor Unc5H2; unc-5 homolog 2; unc-5 homolog B; UNC5H2
Mus musculus (house mouse) : Unc5b (unc-5 netrin receptor B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Unc5b (unc-5 netrin receptor B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Unc5b (unc-5 netrin receptor B)
Pan paniscus (bonobo/pygmy chimpanzee) : UNC5B (unc-5 netrin receptor B)
Canis lupus familiaris (dog) : UNC5B (unc-5 netrin receptor B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Unc5b (unc-5 netrin receptor B)
Sus scrofa (pig) : UNC5B (unc-5 netrin receptor B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381071,212,535 - 71,302,879 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371072,972,292 - 73,062,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,642,353 - 72,729,722 (+)NCBINCBI36hg18NCBI36
Build 341072,642,354 - 72,729,714NCBI
Celera1066,254,788 - 66,343,547 (+)NCBI
Cytogenetic Map10q22.1NCBI
HuRef1066,966,129 - 67,056,670 (+)NCBIHuRef
CHM1_11073,254,992 - 73,345,299 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on UNC5B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736493
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-22
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.