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Gene: CYP11B2 (cytochrome P450 family 11 subfamily B member 2) Homo sapiens
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Symbol: CYP11B2
Name: cytochrome P450 family 11 subfamily B member 2
Description: Exhibits heme binding activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including monovalent inorganic cation homeostasis; regulation of blood volume by renal aldosterone; and steroid hormone biosynthetic process. Localizes to the mitochondrion. Implicated in diabetes mellitus (multiple); dilated cardiomyopathy 1H; hypertension (multiple); and primary hyperaldosteronism. Biomarker of adrenal cortical adenoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALDOS; aldosterone synthase; aldosterone-synthesizing enzyme; corticosterone 18-monooxygenase, CYP11B2; CPN2; CYP11B; CYP11BL; CYPXIB2; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450 11B2, mitochondrial; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome p450, subfamily 11b, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P-450C18; P450aldo; P450C18; steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl8142,910,559 - 142,917,843 (-)Ensembl
GRCh388142,910,559 - 142,917,843 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378143,991,975 - 143,999,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,988,977 - 143,996,261 (-)NCBINCBI36hg18NCBI36
Build 348143,988,976 - 143,996,261NCBI
Celera8140,301,421 - 140,308,694 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8139,244,244 - 139,251,515 (-)NCBIHuRef
CHM1_18144,032,236 - 144,039,525 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Comparative Map Data
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on CYP11B2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736494
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.