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Gene: MAPT (microtubule associated protein tau) Homo sapiens
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Symbol: MAPT
Name: microtubule associated protein tau
Description: Exhibits several functions, including Hsp90 protein binding activity; SH3 domain binding activity; and chaperone binding activity. Involved in several processes, including protein-containing complex assembly; regulation of cellular protein localization; and regulation of cellular response to stress. Localizes to several cellular components, including axon; cytoskeleton; and nuclear lumen. Colocalizes with membrane. Implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Biomarker of Alzheimer's disease; breast cancer; and tauopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; MGC138549; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; TAU
Orthologs:
Mus musculus (house mouse) : Mapt (microtubule-associated protein tau)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mapt (microtubule-associated protein tau)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapt (microtubule associated protein tau)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPT (microtubule associated protein tau)
Canis lupus familiaris (dog) : MAPT (microtubule associated protein tau)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapt (microtubule associated protein tau)
Sus scrofa (pig) : MAPT (microtubule associated protein tau)
Chlorocebus sabaeus (African green monkey) : MAPT (microtubule associated protein tau)
Heterocephalus glaber (naked mole-rat) : Mapt (microtubule associated protein tau)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SHR-Tg(Thy1-MAPT)318   SHR-Tg(Thy1-MAPT)72  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1745,894,382 - 46,028,334 (+)EnsemblGRCh38hg38GRCh38
GRCh381745,894,382 - 46,028,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371743,971,702 - 44,105,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361741,327,624 - 41,461,547 (+)NCBINCBI36hg18NCBI36
Build 341741,327,623 - 41,458,611NCBI
Celera1740,619,037 - 40,753,014 (+)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1739,635,406 - 39,768,427 (+)NCBIHuRef
CHM1_11744,218,591 - 44,352,524 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Nucleotide Sequences