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Gene: Mapt (microtubule-associated protein tau) Mus musculus
Symbol: Mapt
Name: microtubule-associated protein tau
CRRD ID: 736497
Description: Exhibits DNA binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including generation of neurons; regulation of cellular response to stress; and transport along microtubule. Localizes to several cellular components, including cytoskeleton; membrane raft; and postsynaptic density. Predicted to colocalize with membrane and microtubule. Is expressed in several structures, including gut; nervous system; sensory organ; smooth muscle tissue; and urinary system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau); PARTICIPATES IN Reelin signaling pathway; Alzheimer's disease pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (Z)-ligustilide; 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI413597; AW045860; Mta; Mtapt; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; Ta; Tau
Homo sapiens (human) : MAPT (microtubule associated protein tau)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mapt (microtubule-associated protein tau)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapt (microtubule associated protein tau)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPT (microtubule associated protein tau)
Canis lupus familiaris (dog) : MAPT (microtubule associated protein tau)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapt (microtubule associated protein tau)
Sus scrofa (pig) : MAPT (microtubule associated protein tau)
Chlorocebus sabaeus (African green monkey) : MAPT (microtubule associated protein tau)
Heterocephalus glaber (naked mole-rat) : Mapt (microtubule associated protein tau)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl11104,231,390 - 104,332,090 (+)EnsemblGRCm38mm10GRCm38
GRCm3811104,229,409 - 104,332,090 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711104,092,750 - 104,193,410 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611104,047,526 - 104,148,186 (+)NCBImm8
Celera11115,951,246 - 116,057,990 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mapt
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736497
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.