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Gene: Mapt (microtubule-associated protein tau) Mus musculus
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Symbol: Mapt
Name: microtubule-associated protein tau
CRRD ID: 736497
Description: Exhibits DNA binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including generation of neurons; regulation of cellular response to stress; and transport along microtubule. Localizes to several cellular components, including cytoskeleton; membrane raft; and postsynaptic density. Predicted to colocalize with membrane and microtubule. Is expressed in several structures, including gut; nervous system; sensory organ; smooth muscle tissue; and urinary system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau); PARTICIPATES IN Reelin signaling pathway; Alzheimer's disease pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (Z)-ligustilide; 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI413597; AW045860; Mta; Mtapt; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; Ta; Tau
Orthologs:
Homo sapiens (human) : MAPT (microtubule associated protein tau)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mapt (microtubule-associated protein tau)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapt (microtubule associated protein tau)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPT (microtubule associated protein tau)
Canis lupus familiaris (dog) : MAPT (microtubule associated protein tau)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapt (microtubule associated protein tau)
Sus scrofa (pig) : MAPT (microtubule associated protein tau)
Chlorocebus sabaeus (African green monkey) : MAPT (microtubule associated protein tau)
Heterocephalus glaber (naked mole-rat) : Mapt (microtubule associated protein tau)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl11104,231,390 - 104,332,090 (+)EnsemblGRCm38mm10GRCm38
GRCm3811104,229,409 - 104,332,090 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711104,092,750 - 104,193,410 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611104,047,526 - 104,148,186 (+)NCBImm8
Celera11115,951,246 - 116,057,990 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Mapt
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736497
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.