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Gene: ALAD (aminolevulinate dehydratase) Homo sapiens
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Symbol: ALAD
Name: aminolevulinate dehydratase
Description: Exhibits identical protein binding activity; porphobilinogen synthase activity; and zinc ion binding activity. Involved in heme biosynthetic process; negative regulation of proteasomal protein catabolic process; and protein homooligomerization. Localizes to the extracellular exosome and nucleus. Implicated in porphyria cutanea tarda and sickle cell anemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALADH; aminolevulinate, delta-, dehydratase; delta-aminolevulinic acid dehydratase; MGC5057; PBGS; porphobilinogen synthase; testicular tissue protein Li 95
Orthologs:
Mus musculus (house mouse) : Alad (aminolevulinate, delta-, dehydratase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Alad (aminolevulinate dehydratase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alad (aminolevulinate dehydratase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALAD (aminolevulinate dehydratase)
Canis lupus familiaris (dog) : ALAD (aminolevulinate dehydratase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alad (aminolevulinate dehydratase)
Sus scrofa (pig) : ALAD (aminolevulinate dehydratase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389113,386,312 - 113,401,338 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379116,148,592 - 116,163,618 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,188,413 - 115,203,391 (-)NCBINCBI36hg18NCBI36
Build 349113,228,146 - 113,243,124NCBI
Celera986,796,194 - 86,811,219 (-)NCBI
Cytogenetic Map9q32NCBI
HuRef985,755,612 - 85,770,551 (-)NCBIHuRef
CHM1_19116,295,230 - 116,310,254 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ALAD
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736545
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.