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Gene: ALAD (aminolevulinate dehydratase) Homo sapiens
Symbol: ALAD
Name: aminolevulinate dehydratase
Description: Exhibits identical protein binding activity; porphobilinogen synthase activity; and zinc ion binding activity. Involved in heme biosynthetic process; negative regulation of proteasomal protein catabolic process; and protein homooligomerization. Localizes to the extracellular exosome and nucleus. Implicated in porphyria cutanea tarda and sickle cell anemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALADH; aminolevulinate, delta-, dehydratase; delta-aminolevulinic acid dehydratase; MGC5057; PBGS; porphobilinogen synthase; testicular tissue protein Li 95
Mus musculus (house mouse) : Alad (aminolevulinate, delta-, dehydratase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Alad (aminolevulinate dehydratase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alad (aminolevulinate dehydratase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALAD (aminolevulinate dehydratase)
Canis lupus familiaris (dog) : ALAD (aminolevulinate dehydratase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alad (aminolevulinate dehydratase)
Sus scrofa (pig) : ALAD (aminolevulinate dehydratase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389113,386,312 - 113,401,338 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379116,148,592 - 116,163,618 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,188,413 - 115,203,391 (-)NCBINCBI36hg18NCBI36
Build 349113,228,146 - 113,243,124NCBI
Celera986,796,194 - 86,811,219 (-)NCBI
Cytogenetic Map9q32NCBI
HuRef985,755,612 - 85,770,551 (-)NCBIHuRef
CHM1_19116,295,230 - 116,310,254 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ALAD
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736545
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.