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Gene: PPT1 (palmitoyl-protein thioesterase 1) Homo sapiens
Symbol: PPT1
Name: palmitoyl-protein thioesterase 1
Description: Exhibits palmitoyl-(protein) hydrolase activity and palmitoyl-CoA hydrolase activity. Involved in several processes, including endocytosis; lysosomal lumen acidification; and positive regulation of endocytosis. Localizes to several cellular components, including the Golgi apparatus; membrane raft; and synaptic vesicle. Implicated in neuronal ceroid lipofuscinosis 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ceroid-palmitoyl-palmitoyl-protein thioesterase 1; CLN1; INCL; palmitoyl-protein hydrolase 1; palmitoyl-protein thioesterase; PPT; PPT-1
Mus musculus (house mouse) : Ppt1 (palmitoyl-protein thioesterase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppt1 (palmitoyl-protein thioesterase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppt1 (palmitoyl-protein thioesterase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PPT1 (palmitoyl-protein thioesterase 1)
Canis lupus familiaris (dog) : PPT1 (palmitoyl-protein thioesterase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppt1 (palmitoyl-protein thioesterase 1)
Sus scrofa (pig) : PPT1 (palmitoyl-protein thioesterase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38140,071,461 - 40,097,470 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37140,538,382 - 40,563,142 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,310,969 - 40,335,555 (-)NCBINCBI36hg18NCBI36
Build 34140,207,476 - 40,232,061NCBI
Celera138,820,669 - 38,845,442 (-)NCBI
Cytogenetic Map1p34.2NCBI
HuRef138,656,433 - 38,681,192 (-)NCBIHuRef
CHM1_1140,653,983 - 40,678,773 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PPT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736552
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.