Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pdha1 (pyruvate dehydrogenase E1 alpha 1) Mus musculus
Symbol: Pdha1
Name: pyruvate dehydrogenase E1 alpha 1
Description: Exhibits pyruvate dehydrogenase (NAD+) activity. Involved in mitochondrial acetyl-CoA biosynthetic process from pyruvate. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 alpha 1 subunit); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrabromodibenzodioxine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Pdha-1; PDHE1-A type I; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1alpha subunit
Homo sapiens (human) : PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdha1 (pyruvate dehydrogenase E1 alpha 1 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : PDHA1 (pyruvate dehydrogenase E1 alpha 1 subunit)
Canis lupus familiaris (dog) : PDHA1 (pyruvate dehydrogenase E1 alpha 1 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdha1 (pyruvate dehydrogenase E1 alpha 1 subunit)
Sus scrofa (pig) : PDHA1 (pyruvate dehydrogenase E1 alpha 1 subunit)
more info ...
Related Pseudogenes: 4930519F09Rik  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 EnsemblX160,122,209 - 160,138,413 (-)Ensembl
GRCm38X160,122,219 - 160,138,430 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X156,560,151 - 156,576,268 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X155,466,324 - 155,482,441 (-)NCBImm8
CeleraX143,366,647 - 143,382,812 (-)NCBICelera
Cytogenetic MapX F4NCBI
cM MapX73.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pdha1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736557
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.