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Gene: Pdha1 (pyruvate dehydrogenase E1 alpha 1) Mus musculus
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Symbol: Pdha1
Name: pyruvate dehydrogenase E1 alpha 1
Description: Exhibits pyruvate dehydrogenase (NAD+) activity. Involved in mitochondrial acetyl-CoA biosynthetic process from pyruvate. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 alpha 1 subunit); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrabromodibenzodioxine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Pdha-1; PDHE1-A type I; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1alpha subunit
Orthologs:
Homo sapiens (human) : PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdha1 (pyruvate dehydrogenase E1 alpha 1 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : PDHA1 (pyruvate dehydrogenase E1 alpha 1 subunit)
Canis lupus familiaris (dog) : PDHA1 (pyruvate dehydrogenase E1 alpha 1 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdha1 (pyruvate dehydrogenase E1 alpha 1 subunit)
Sus scrofa (pig) : PDHA1 (pyruvate dehydrogenase E1 alpha 1 subunit)
more info ...
Related Pseudogenes: 4930519F09Rik  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 EnsemblX160,122,209 - 160,138,413 (-)Ensembl
GRCm38X160,122,219 - 160,138,430 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X156,560,151 - 156,576,268 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X155,466,324 - 155,482,441 (-)NCBImm8
CeleraX143,366,647 - 143,382,812 (-)NCBICelera
Cytogenetic MapX F4NCBI
cM MapX73.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pdha1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736557
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.