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Gene: EPHX1 (epoxide hydrolase 1) Homo sapiens
Symbol: EPHX1
Name: epoxide hydrolase 1
Description: Exhibits epoxide hydrolase activity. Involved in epoxide metabolic process. Predicted to localize to the endoplasmic reticulum membrane. Implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Biomarker of Alzheimer's disease and lung non-small cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EPHX; EPOX; epoxide hydratase; epoxide hydrolase 1 microsomal; epoxide hydrolase 1, microsomal (xenobiotic); HYL1; MEH
Mus musculus (house mouse) : Ephx1 (epoxide hydrolase 1, microsomal)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ephx1 (epoxide hydrolase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ephx1 (epoxide hydrolase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHX1 (epoxide hydrolase 1)
Canis lupus familiaris (dog) : EPHX1 (epoxide hydrolase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ephx1 (epoxide hydrolase 1)
Sus scrofa (pig) : EPHX1 (epoxide hydrolase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381225,810,074 - 225,845,563 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371225,997,797 - 226,033,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,079,599 - 224,099,884 (+)NCBINCBI36hg18NCBI36
Build 341222,319,710 - 222,339,996NCBI
Celera1199,188,853 - 199,224,327 (+)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1196,515,661 - 196,550,964 (+)NCBIHuRef
CHM1_11227,270,100 - 227,305,585 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EPHX1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736560
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.