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Gene: Lipa (lysosomal acid lipase A) Mus musculus
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Symbol: Lipa
Name: lysosomal acid lipase A
Description: Predicted to have sterol esterase activity. Involved in several processes, including homeostasis of number of cells within a tissue; lung development; and tissue remodeling. Predicted to localize to fibrillar center and lysosome. Used to study Wolman disease and lysosomal and lipase deficiency. Human ortholog(s) of this gene implicated in Wolman disease; cholesterol ester storage disease; and lysosomal and lipase deficiency. Is expressed in several structures, including adrenal cortex zone; alimentary system; brain; hemolymphoid system; and metanephros. Orthologous to human LIPA (lipase A, lysosomal acid type); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA960673; acid cholesteryl ester hydrolase; cholesteryl esterase; Lal; Lip-1; Lip1; lipase A; lysosomal acid lipase 1; lysosomal acid lipase/cholesteryl ester hydrolase; sterol esterase
Orthologs:
Homo sapiens (human) : LIPA (lipase A, lysosomal acid type)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lipa (lipase A, lysosomal acid type)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lipa (lipase A, lysosomal acid type)
Pan paniscus (bonobo/pygmy chimpanzee) : LIPA (lipase A, lysosomal acid type)
Canis lupus familiaris (dog) : LIPA (lipase A, lysosomal acid type)
Sus scrofa (pig) : LIPA (lipase A, lysosomal acid type)
Chlorocebus sabaeus (African green monkey) : LIPA (lipase A, lysosomal acid type)
Heterocephalus glaber (naked mole-rat) : Lipa (lipase A, lysosomal acid type)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1934,492,318 - 34,527,474 (-)EnsemblGRCm38mm10GRCm38
GRCm381934,492,316 - 34,527,474 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371934,566,806 - 34,601,964 (-)NCBIGRCm37mm9NCBIm37
MGSCv361934,558,313 - 34,593,419 (-)NCBImm8
Celera1935,267,889 - 35,303,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lipa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736563
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.