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Gene: Lipa (lysosomal acid lipase A) Mus musculus
Symbol: Lipa
Name: lysosomal acid lipase A
Description: Predicted to have sterol esterase activity. Involved in several processes, including homeostasis of number of cells within a tissue; lung development; and tissue remodeling. Predicted to localize to fibrillar center and lysosome. Used to study Wolman disease and lysosomal and lipase deficiency. Human ortholog(s) of this gene implicated in Wolman disease; cholesterol ester storage disease; and lysosomal and lipase deficiency. Is expressed in several structures, including adrenal cortex zone; alimentary system; brain; hemolymphoid system; and metanephros. Orthologous to human LIPA (lipase A, lysosomal acid type); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA960673; acid cholesteryl ester hydrolase; cholesteryl esterase; Lal; Lip-1; Lip1; lipase A; lysosomal acid lipase 1; lysosomal acid lipase/cholesteryl ester hydrolase; sterol esterase
Homo sapiens (human) : LIPA (lipase A, lysosomal acid type)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lipa (lipase A, lysosomal acid type)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lipa (lipase A, lysosomal acid type)
Pan paniscus (bonobo/pygmy chimpanzee) : LIPA (lipase A, lysosomal acid type)
Canis lupus familiaris (dog) : LIPA (lipase A, lysosomal acid type)
Sus scrofa (pig) : LIPA (lipase A, lysosomal acid type)
Chlorocebus sabaeus (African green monkey) : LIPA (lipase A, lysosomal acid type)
Heterocephalus glaber (naked mole-rat) : Lipa (lipase A, lysosomal acid type)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1934,492,318 - 34,527,474 (-)EnsemblGRCm38mm10GRCm38
GRCm381934,492,316 - 34,527,474 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371934,566,806 - 34,601,964 (-)NCBIGRCm37mm9NCBIm37
MGSCv361934,558,313 - 34,593,419 (-)NCBImm8
Celera1935,267,889 - 35,303,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lipa
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736563
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.