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Gene: AXIN1 (axin 1) Homo sapiens
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Symbol: AXIN1
Name: axin 1
Description: Exhibits several functions, including I-SMAD binding activity; beta-catenin binding activity; and ubiquitin protein ligase binding activity. Involved in cellular protein-containing complex assembly; negative regulation of canonical Wnt signaling pathway; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including the beta-catenin destruction complex; lateral plasma membrane; and perinuclear region of cytoplasm. Implicated in hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AXIN; axin-1; axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; gsk-3beta interacting protein raxin; hAxin; MGC52315; PPP1R49; protein phosphatase 1, regulatory subunit 49
Orthologs:
Mus musculus (house mouse) : Axin1 (axin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Axin1 (axin 1)
Chinchilla lanigera (long-tailed chinchilla) : Axin1 (axin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AXIN1 (axin 1)
Canis lupus familiaris (dog) : AXIN1 (axin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Axin1 (axin 1)
Sus scrofa (pig) : AXIN1 (axin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816287,440 - 355,226 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716337,440 - 405,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616277,441 - 342,465 (-)NCBINCBI36hg18NCBI36
Build 3416277,440 - 342,465NCBI
Celera16537,339 - 602,420 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef16255,743 - 344,360 (-)NCBIHuRef
CHM1_116337,402 - 402,637 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on AXIN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736564
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.