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Gene: Akr1b3 (aldo-keto reductase family 1, member B3 (aldose reductase)) Mus musculus
Symbol: Akr1b3
Name: aldo-keto reductase family 1, member B3 (aldose reductase)
CRRD ID: 736610
Description: Exhibits alditol:NADP+ 1-oxidoreductase activity. Involved in several processes, including epithelial cell maturation; metanephric collecting duct development; and renal water homeostasis. Predicted to localize to several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B); PARTICIPATES IN D-glycericacidemia pathway; dopa responsive dystonia pathway; familial lipoprotein lipase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; Ah; Ahr; Ahr-1; Ahr1; Akr1b1; Al; aldehyde reductase 1; aldo-keto reductase family 1 member B1; aldo-keto reductase family 1 member B3; aldo-keto reductase family 1, member B1 (aldose reductase); Aldor1; aldose reductase; Aldr1; ALR2; AR
Homo sapiens (human) : AKR1B1 (aldo-keto reductase family 1 member B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Akr1b1 (aldo-keto reductase family 1 member B)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : AKR1B1 (aldo-keto reductase family 1 member B)
Canis lupus familiaris (dog) : AKR1B1 (aldo-keto reductase family 1 member B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akr1b1 (aldo-keto reductase family 1 member B)
Sus scrofa (pig) : AKR1B1 (aldo-keto reductase family 1 member B)
Chlorocebus sabaeus (African green monkey) : AKR1B1 (aldo-keto reductase family 1 member B)
more info ...
Related Pseudogenes: Gm12015   Gm12138   Gm13983   Gm5395   Gm6122   Gm6644   Gm6736   Gm7678  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39634,280,865 - 34,294,424 (-)NCBI
GRCm38634,303,930 - 34,317,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,302,434 - 34,317,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv37634,253,930 - 34,267,489 (-)NCBIGRCm37mm9NCBIm37
MGSCv36634,234,092 - 34,247,629 (-)NCBImm8
Celera634,300,847 - 34,314,402 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map614.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Akr1b3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736610
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.