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Gene: Akr1b3 (aldo-keto reductase family 1, member B3 (aldose reductase)) Mus musculus
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Symbol: Akr1b3
Name: aldo-keto reductase family 1, member B3 (aldose reductase)
CRRD ID: 736610
Description: Exhibits alditol:NADP+ 1-oxidoreductase activity. Involved in several processes, including epithelial cell maturation; metanephric collecting duct development; and renal water homeostasis. Predicted to localize to several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B); PARTICIPATES IN D-glycericacidemia pathway; dopa responsive dystonia pathway; familial lipoprotein lipase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; Ah; Ahr; Ahr-1; Ahr1; Akr1b1; Al; aldehyde reductase 1; aldo-keto reductase family 1 member B1; aldo-keto reductase family 1 member B3; aldo-keto reductase family 1, member B1 (aldose reductase); Aldor1; aldose reductase; Aldr1; ALR2; AR
Orthologs:
Homo sapiens (human) : AKR1B1 (aldo-keto reductase family 1 member B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Akr1b1 (aldo-keto reductase family 1 member B)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : AKR1B1 (aldo-keto reductase family 1 member B)
Canis lupus familiaris (dog) : AKR1B1 (aldo-keto reductase family 1 member B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akr1b1 (aldo-keto reductase family 1 member B)
Sus scrofa (pig) : AKR1B1 (aldo-keto reductase family 1 member B)
Chlorocebus sabaeus (African green monkey) : AKR1B1 (aldo-keto reductase family 1 member B)
more info ...
Related Pseudogenes: Gm12015   Gm12138   Gm13983   Gm5395   Gm6122   Gm6644   Gm6736   Gm7678  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,280,865 - 34,294,424 (-)NCBI
GRCm38634,303,930 - 34,317,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,302,434 - 34,317,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv37634,253,930 - 34,267,489 (-)NCBIGRCm37mm9NCBIm37
MGSCv36634,234,092 - 34,247,629 (-)NCBImm8
Celera634,300,847 - 34,314,402 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map614.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Akr1b3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736610
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.