NEDD4 (NEDD4 E3 ubiquitin protein ligase) - Chinchilla Research Resource Database
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Gene: NEDD4 (NEDD4 E3 ubiquitin protein ligase) Homo sapiens
Analyze
Symbol: NEDD4
Name: NEDD4 E3 ubiquitin protein ligase
CRRD ID: 736612
Description: Exhibits several functions, including beta-2 adrenergic receptor binding activity; sodium channel inhibitor activity; and ubiquitin protein ligase activity. Involved in several processes, including intracellular steroid hormone receptor signaling pathway; receptor metabolic process; and regulation of ion transmembrane transporter activity. Localizes to several cellular components, including Golgi apparatus; chromatin; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; HECT-type E3 ubiquitin transferase NEDD4; KIAA0093; MGC176705; NEDD-4; NEDD4-1; neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4a; receptor-potentiating factor 1; RPF1
Orthologs:
Mus musculus (house mouse) : Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
Sus scrofa (pig) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Chlorocebus sabaeus (African green monkey) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Heterocephalus glaber (naked mole-rat) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1555,826,922 - 55,993,746 (-)EnsemblGRCh38hg38GRCh38
GRCh381555,826,917 - 55,993,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371556,119,120 - 56,285,835 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361553,906,412 - 54,073,127 (-)NCBINCBI36hg18NCBI36
Build 341553,906,420 - 53,996,621NCBI
Celera1533,007,634 - 33,174,352 (-)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1532,943,160 - 33,109,724 (-)NCBIHuRef
CHM1_11556,237,527 - 56,404,286 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
avobenzone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP)
desmopressin  (ISO)
dextran sulfate  (ISO)
dicrotophos  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indoles  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
lithium chloride  (ISO)
melatonin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP,ISO)
nickel subsulfide  (ISO)
olanzapine  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
resveratrol  (ISO)
SB 203580  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sunitinib  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)
warfarin  (EXP)
wortmannin  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
blood vessel morphogenesis  (ISO)
cellular response to UV  (IMP)
development involved in symbiotic interaction  (IMP)
endocardial cushion development  (ISO)
glucocorticoid receptor signaling pathway  (IDA)
immune response  (ISO)
lysosomal transport  (IDA)
negative regulation of sodium ion transmembrane transporter activity  (IBA,IDA)
negative regulation of sodium ion transport  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  (IMP)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (ISS)
neuromuscular junction development  (IBA)
neuron projection development  (IBA,IEP)
outflow tract morphogenesis  (ISO)
positive regulation of nucleocytoplasmic transport  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IMP)
positive regulation of protein catabolic process  (IBA,IDA)
progesterone receptor signaling pathway  (IDA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IBA)
protein K63-linked ubiquitination  (ISS)
protein monoubiquitination  (ISO)
protein polyubiquitination  (IBA)
protein targeting to lysosome  (IBA)
protein ubiquitination  (IBA,IDA,IEA)
receptor catabolic process  (IBA,IDA)
receptor internalization  (IBA,IDA)
regulation of dendrite morphogenesis  (IBA,ISS)
regulation of ion transmembrane transport  (IDA)
regulation of macroautophagy  (TAS)
regulation of membrane potential  (IDA)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of potassium ion transmembrane transporter activity  (IDA)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (ISO)
regulation of synapse organization  (IBA)
response to calcium ion  (TAS)
response to denervation involved in regulation of muscle adaptation  (ISO)
T cell activation  (ISO)
ubiquitin-dependent protein catabolic process  (IBA,IDA,IMP)
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  (IMP)
viral budding  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7788527   PMID:8649367   PMID:9073511   PMID:9182527   PMID:9305852   PMID:9351815   PMID:9405440   PMID:9525617   PMID:9593687   PMID:9990509   PMID:10037602   PMID:10212229  
PMID:10446181   PMID:10490634   PMID:10642508   PMID:10871286   PMID:11042109   PMID:11046148   PMID:11087859   PMID:11087860   PMID:11112487   PMID:11244092   PMID:11323714   PMID:11342538  
PMID:11359767   PMID:11502596   PMID:11598133   PMID:11696533   PMID:11717310   PMID:11748237   PMID:11870222   PMID:11919637   PMID:11991975   PMID:12050153   PMID:12167593   PMID:12218189  
PMID:12230472   PMID:12477932   PMID:12610113   PMID:12697834   PMID:12729930   PMID:12796489   PMID:12890487   PMID:12907594   PMID:12907674   PMID:14581525   PMID:14645220   PMID:14973438  
PMID:15001356   PMID:15013426   PMID:15060076   PMID:15105431   PMID:15126635   PMID:15217910   PMID:15231748   PMID:15252135   PMID:15496141   PMID:15548568   PMID:15677482   PMID:15678106  
PMID:15703212   PMID:16000308   PMID:16055720   PMID:16118794   PMID:16138902   PMID:16169070   PMID:16338389   PMID:16572171   PMID:16701206   PMID:16867982   PMID:16885233   PMID:17013377  
PMID:17116753   PMID:17218260   PMID:17218261   PMID:17289006   PMID:17426036   PMID:17538020   PMID:17544362   PMID:17588522   PMID:17719543   PMID:17996703   PMID:18174164   PMID:18287095  
PMID:18305167   PMID:18307411   PMID:18353951   PMID:18498243   PMID:18498246   PMID:18544533   PMID:18577513   PMID:18632619   PMID:18703514   PMID:18723765   PMID:18772139   PMID:18804462  
PMID:18854154   PMID:19020832   PMID:19024597   PMID:19054764   PMID:19143627   PMID:19158374   PMID:19165858   PMID:19193720   PMID:19240029   PMID:19252184   PMID:19345329   PMID:19366705  
PMID:19602703   PMID:19615332   PMID:19617352   PMID:19670909   PMID:19706893   PMID:19812267   PMID:19835589   PMID:19835873   PMID:19864419   PMID:19907029   PMID:19953087   PMID:20051513  
PMID:20062064   PMID:20078934   PMID:20086093   PMID:20159449   PMID:20164219   PMID:20172859   PMID:20237237   PMID:20332230   PMID:20519395   PMID:20522958   PMID:20530479   PMID:20559325  
PMID:20562859   PMID:20676133   PMID:20697350   PMID:20711176   PMID:20730100   PMID:20737472   PMID:20819705   PMID:20843805   PMID:20855896   PMID:20889565   PMID:21148011   PMID:21191027  
PMID:21308777   PMID:21332718   PMID:21338354   PMID:21399620   PMID:21463633   PMID:21478478   PMID:21572392   PMID:21666754   PMID:21685363   PMID:21765395   PMID:21813641   PMID:21852580  
PMID:21873635   PMID:21936852   PMID:21953697   PMID:21986318   PMID:22004035   PMID:22024150   PMID:22096579   PMID:22350919   PMID:22361880   PMID:22385262   PMID:22467858   PMID:22751010  
PMID:22761998   PMID:22762019   PMID:22768111   PMID:22773947   PMID:22875931   PMID:22939629   PMID:22974840   PMID:22992774   PMID:23071112   PMID:23106887   PMID:23146885   PMID:23166351  
PMID:23175188   PMID:23180960   PMID:23195959   PMID:23208550   PMID:23253940   PMID:23262292   PMID:23287719   PMID:23305486   PMID:23460917   PMID:23471985   PMID:23533145   PMID:23549616  
PMID:23589096   PMID:23602387   PMID:23603909   PMID:23639431   PMID:23644597   PMID:23665454   PMID:23686771   PMID:23827681   PMID:23964096   PMID:24063548   PMID:24107629   PMID:24141722  
PMID:24292274   PMID:24340059   PMID:24379409   PMID:24413081   PMID:24489825   PMID:24496234   PMID:24614057   PMID:24657926   PMID:24662824   PMID:24743017   PMID:24746824   PMID:24831002  
PMID:24907641   PMID:24981860   PMID:25047839   PMID:25092867   PMID:25216516   PMID:25292214   PMID:25384981   PMID:25395181   PMID:25438670   PMID:25527121   PMID:25547115   PMID:25588945  
PMID:25631046   PMID:25692647   PMID:25809873   PMID:25823820   PMID:25879670   PMID:25883222   PMID:25921289   PMID:25963657   PMID:26006083   PMID:26037357   PMID:26147758   PMID:26186194  
PMID:26193427   PMID:26205498   PMID:26263374   PMID:26280536   PMID:26296893   PMID:26304770   PMID:26344197   PMID:26371805   PMID:26503960   PMID:26556890   PMID:26685112   PMID:26720344  
PMID:26823285   PMID:26854353   PMID:26904956   PMID:26949039   PMID:27173227   PMID:27182664   PMID:27226107   PMID:27295432   PMID:27445338   PMID:27466427   PMID:27467187   PMID:27494837  
PMID:27557663   PMID:27793840   PMID:27917940   PMID:28069708   PMID:28085563   PMID:28126338   PMID:28128446   PMID:28218281   PMID:28292929   PMID:28300060   PMID:28320822   PMID:28379054  
PMID:28405688   PMID:28423617   PMID:28425671   PMID:28437168   PMID:28470758   PMID:28471472   PMID:28475870   PMID:28514442   PMID:28536267   PMID:28608480   PMID:28627598   PMID:28666866  
PMID:28674435   PMID:28714370   PMID:28733455   PMID:28745938   PMID:28794017   PMID:28877262   PMID:28931009   PMID:28986522   PMID:29021346   PMID:29251248   PMID:29263404   PMID:29271375  
PMID:29416926   PMID:29449217   PMID:29455656   PMID:29463679   PMID:29467225   PMID:29480061   PMID:29507755   PMID:29582580   PMID:29593330   PMID:29643511   PMID:29760280   PMID:29851245  
PMID:29897283   PMID:29964046   PMID:30021884   PMID:30118678   PMID:30224337   PMID:30254168   PMID:30273597   PMID:30287686   PMID:30367623   PMID:30385740   PMID:30471916   PMID:30573683  
PMID:30587574   PMID:30594392   PMID:30708959   PMID:30772377   PMID:30854719   PMID:30972179   PMID:31159502   PMID:31326389   PMID:31357244   PMID:31373553   PMID:31390487   PMID:31423749  
PMID:31451218   PMID:31469661   PMID:31578285   PMID:31605013   PMID:31614475   PMID:31636332   PMID:31690112   PMID:31831018   PMID:31849325   PMID:31856858   PMID:31867777   PMID:31916733  
PMID:31974380   PMID:32296183  


Genomics

Comparative Map Data
NEDD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1555,826,922 - 55,993,746 (-)EnsemblGRCh38hg38GRCh38
GRCh381555,826,917 - 55,993,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371556,119,120 - 56,285,835 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361553,906,412 - 54,073,127 (-)NCBINCBI36hg18NCBI36
Build 341553,906,420 - 53,996,621NCBI
Celera1533,007,634 - 33,174,352 (-)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1532,943,160 - 33,109,724 (-)NCBIHuRef
CHM1_11556,237,527 - 56,404,286 (-)NCBICHM1_1
Nedd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39972,569,613 - 72,657,133 (+)NCBI
GRCm38972,662,331 - 72,749,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl972,662,346 - 72,749,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv37972,510,154 - 72,597,655 (+)NCBIGRCm37mm9NCBIm37
MGSCv36972,460,914 - 72,548,414 (+)NCBImm8
Celera969,852,010 - 69,939,539 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map940.08NCBI
Nedd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0879,323,408 - 79,408,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl879,323,408 - 79,408,833 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0873,679,012 - 73,764,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4877,252,500 - 77,337,402 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1877,271,630 - 77,353,830 (+)NCBI
Celera868,281,153 - 68,365,646 (-)NCBICelera
Cytogenetic Map8q24NCBI
Nedd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955409183,545 - 281,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955409183,645 - 281,252 (+)NCBIChiLan1.0ChiLan1.0
NEDD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11553,118,400 - 53,283,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1553,118,411 - 53,283,076 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01534,798,880 - 34,963,823 (-)NCBIMhudiblu_PPA_v0panPan3
NEDD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3021,126,043 - 21,229,870 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13021,123,333 - 21,229,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nedd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647117,254,777 - 17,374,725 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,941,937 - 116,070,317 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,941,945 - 116,069,884 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21128,545,541 - 128,557,317 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2627,487,796 - 27,655,992 (+)Ensembl
ChlSab1.12627,487,652 - 27,655,742 (+)NCBI
Nedd4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247315,855,678 - 5,954,119 (+)NCBI

Position Markers
SHGC-31455  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371556,173,905 - 56,174,029UniSTSGRCh37
Build 361553,961,197 - 53,961,321RGDNCBI36
Celera1533,062,404 - 33,062,528RGD
Cytogenetic Map15qUniSTS
HuRef1532,997,897 - 32,998,021UniSTS
Stanford-G3 RH Map151649.0UniSTS
NCBI RH Map15288.0UniSTS
GeneMap99-G3 RH Map151649.0UniSTS
RH25321  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371556,120,338 - 56,120,828UniSTSGRCh37
Build 361553,907,630 - 53,908,120RGDNCBI36
Celera1533,008,852 - 33,009,342RGD
Cytogenetic Map15qUniSTS
HuRef1532,944,373 - 32,944,863UniSTS
GeneMap99-GB4 RH Map15200.96UniSTS
NCBI RH Map15285.4UniSTS
WI-22810  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371556,173,921 - 56,174,096UniSTSGRCh37
Build 361553,961,213 - 53,961,388RGDNCBI36
Celera1533,062,420 - 33,062,595RGD
Cytogenetic Map15qUniSTS
HuRef1532,997,913 - 32,998,088UniSTS
GeneMap99-GB4 RH Map15193.07UniSTS
Whitehead-RH Map15174.6UniSTS
D15S1324  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371556,121,733 - 56,121,849UniSTSGRCh37
Build 361553,909,025 - 53,909,141RGDNCBI36
Celera1533,010,247 - 33,010,363RGD
Cytogenetic Map15qUniSTS
HuRef1532,945,768 - 32,945,884UniSTS
Stanford-G3 RH Map151640.0UniSTS
GeneMap99-G3 RH Map151640.0UniSTS
STS-D42055  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371556,119,463 - 56,119,596UniSTSGRCh37
Build 361553,906,755 - 53,906,888RGDNCBI36
Celera1533,007,977 - 33,008,110RGD
Cytogenetic Map15qUniSTS
HuRef1532,943,503 - 32,943,636UniSTS
GeneMap99-GB4 RH Map15201.75UniSTS
RH44970  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371556,195,465 - 56,195,564UniSTSGRCh37
Build 361553,982,757 - 53,982,856RGDNCBI36
Celera1533,083,964 - 33,084,063RGD
Cytogenetic Map15qUniSTS
HuRef1533,019,449 - 33,019,548UniSTS
GeneMap99-GB4 RH Map15201.7UniSTS
NCBI RH Map15281.7UniSTS
MARC_17217-17218:1023895765:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371556,208,378 - 56,208,877UniSTSGRCh37
Build 361553,995,670 - 53,996,169RGDNCBI36
Celera1533,096,884 - 33,097,383RGD
HuRef1533,032,364 - 33,032,863UniSTS
NEDD4_4021  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371556,118,958 - 56,119,818UniSTSGRCh37
Build 361553,906,250 - 53,907,110RGDNCBI36
Celera1533,007,472 - 33,008,332RGD
HuRef1532,942,998 - 32,943,858UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7299
Count of miRNA genes:1117
Interacting mature miRNAs:1373
Transcripts:ENST00000338963, ENST00000435532, ENST00000502612, ENST00000503468, ENST00000506154, ENST00000507063, ENST00000508075, ENST00000508342, ENST00000508871, ENST00000513957, ENST00000514893, ENST00000557845
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 282 620 141 117 164 120 1417 862 109 133 213 353 11 53 1162 4
Low 2151 2103 1582 503 1470 342 2938 1330 3257 282 1231 1255 163 1 1151 1626
Below cutoff 1 264 3 2 308 2 3 356 4 7 4 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_051072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001284338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001284339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001284340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_198400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC009997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC039057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY550969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC152452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC152562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D42055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB451823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000338963   ⟹   ENSP00000345530
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,826,922 - 55,917,131 (-)Ensembl
RefSeq Acc Id: ENST00000435532   ⟹   ENSP00000410613
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,826,922 - 55,993,746 (-)Ensembl
RefSeq Acc Id: ENST00000502612   ⟹   ENSP00000424471
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,860,715 - 55,993,548 (-)Ensembl
RefSeq Acc Id: ENST00000503468   ⟹   ENSP00000426051
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,826,922 - 55,916,469 (-)Ensembl
RefSeq Acc Id: ENST00000506154   ⟹   ENSP00000422705
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,827,335 - 55,917,108 (-)Ensembl
RefSeq Acc Id: ENST00000507063   ⟹   ENSP00000421047
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,862,988 - 55,951,400 (-)Ensembl
RefSeq Acc Id: ENST00000508075
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,987,209 - 55,993,602 (-)Ensembl
RefSeq Acc Id: ENST00000508342   ⟹   ENSP00000424827
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,826,922 - 55,917,131 (-)Ensembl
RefSeq Acc Id: ENST00000508871   ⟹   ENSP00000422455
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,826,922 - 55,915,654 (-)Ensembl
RefSeq Acc Id: ENST00000513957
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,924,363 - 55,966,546 (-)Ensembl
RefSeq Acc Id: ENST00000514893
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,862,983 - 55,952,745 (-)Ensembl
RefSeq Acc Id: ENST00000557845
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,987,731 - 55,993,613 (-)Ensembl
RefSeq Acc Id: ENST00000648451   ⟹   ENSP00000498181
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1555,826,997 - 55,993,660 (-)Ensembl
RefSeq Acc Id: NM_001284338   ⟹   NP_001271267
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,922 - 55,917,136 (-)NCBI
HuRef1532,943,155 - 33,109,833 (-)NCBI
CHM1_11556,237,527 - 56,327,687 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001284339   ⟹   NP_001271268
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,917 - 55,917,131 (-)NCBI
HuRef1532,943,155 - 33,109,833 (-)NCBI
CHM1_11556,237,527 - 56,327,687 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001284340   ⟹   NP_001271269
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,917 - 55,917,131 (-)NCBI
HuRef1532,943,155 - 33,109,833 (-)NCBI
CHM1_11556,237,527 - 56,327,687 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329212   ⟹   NP_001316141
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,922 - 55,993,612 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006154   ⟹   NP_006145
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,922 - 55,993,612 (-)NCBI
GRCh371556,119,120 - 56,285,835 (-)ENTREZGENE
Build 361553,906,412 - 54,073,127 (-)NCBI Archive
HuRef1532,943,155 - 33,109,833 (-)NCBI
CHM1_11556,237,527 - 56,404,286 (-)NCBI
Sequence:
RefSeq Acc Id: NM_198400   ⟹   NP_940682
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,917 - 55,917,131 (-)NCBI
GRCh371556,119,120 - 56,285,835 (-)ENTREZGENE
Build 361553,906,412 - 53,996,621 (-)NCBI Archive
HuRef1532,943,155 - 33,109,833 (-)NCBI
CHM1_11556,237,527 - 56,327,687 (-)NCBI
Sequence:
RefSeq Acc Id: NR_104302
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,922 - 55,917,136 (-)NCBI
HuRef1532,943,155 - 33,109,833 (-)NCBI
CHM1_11556,237,527 - 56,327,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011521624   ⟹   XP_011519926
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,922 - 55,952,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011521625   ⟹   XP_011519927
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,922 - 55,993,603 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011521626   ⟹   XP_011519928
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,826,922 - 55,952,745 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006145   ⟸   NM_006154
- Peptide Label: isoform 1
- UniProtKB: P46934 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_940682   ⟸   NM_198400
- Peptide Label: isoform 2
- UniProtKB: P46934 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001271269   ⟸   NM_001284340
- Peptide Label: isoform 5
- UniProtKB: P46934 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001271268   ⟸   NM_001284339
- Peptide Label: isoform 4
- UniProtKB: P46934 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001271267   ⟸   NM_001284338
- Peptide Label: isoform 3
- UniProtKB: P46934 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011519927   ⟸   XM_011521625
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011519928   ⟸   XM_011521626
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011519926   ⟸   XM_011521624
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001316141   ⟸   NM_001329212
- Peptide Label: isoform 6
- UniProtKB: P46934 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000498181   ⟸   ENST00000648451
RefSeq Acc Id: ENSP00000424471   ⟸   ENST00000502612
RefSeq Acc Id: ENSP00000426051   ⟸   ENST00000503468
RefSeq Acc Id: ENSP00000422705   ⟸   ENST00000506154
RefSeq Acc Id: ENSP00000421047   ⟸   ENST00000507063
RefSeq Acc Id: ENSP00000424827   ⟸   ENST00000508342
RefSeq Acc Id: ENSP00000422455   ⟸   ENST00000508871
RefSeq Acc Id: ENSP00000345530   ⟸   ENST00000338963
RefSeq Acc Id: ENSP00000410613   ⟸   ENST00000435532
Protein Domains
C2   HECT   WW

Promoters
RGD ID:6792476
Promoter ID:HG_KWN:21467
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000255016,   UC002ADJ.1,   UC002ADK.1,   UC010BFM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361553,995,821 - 53,996,572 (-)MPROMDB
RGD ID:6792473
Promoter ID:HG_KWN:21469
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000164316
Position:
Human AssemblyChrPosition (strand)Source
Build 361554,072,936 - 54,073,857 (-)MPROMDB
RGD ID:7229593
Promoter ID:EPDNEW_H20542
Type:multiple initiation site
Name:NEDD4_1
Description:neural precursor cell expressed, developmentally down-regulated4, E3 ubiquitin protein ligase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20544  EPDNEW_H20543  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,917,136 - 55,917,196EPDNEW
RGD ID:7229597
Promoter ID:EPDNEW_H20543
Type:initiation region
Name:NEDD4_2
Description:neural precursor cell expressed, developmentally down-regulated4, E3 ubiquitin protein ligase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20542  EPDNEW_H20544  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,993,612 - 55,993,672EPDNEW
RGD ID:7229595
Promoter ID:EPDNEW_H20544
Type:initiation region
Name:NEDD4_3
Description:neural precursor cell expressed, developmentally down-regulated4, E3 ubiquitin protein ligase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20542  EPDNEW_H20543  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381555,993,742 - 55,993,802EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q21.2-22.2(chr15:50864913-59646577)x1 copy number loss See cases [RCV000051621] Chr15:50864913..59646577 [GRCh38]
Chr15:51157110..59938776 [GRCh37]
Chr15:48944402..57726068 [NCBI36]
Chr15:15q21.2-22.2
pathogenic
NM_006154.3(NEDD4):c.763G>A (p.Glu255Lys) single nucleotide variant Malignant melanoma [RCV000062897] Chr15:55860690 [GRCh38]
Chr15:56152888 [GRCh37]
Chr15:53940180 [NCBI36]
Chr15:15q21.3
not provided
GRCh38/hg38 15q21.2-21.3(chr15:51276690-57088386)x1 copy number loss See cases [RCV000136661] Chr15:51276690..57088386 [GRCh38]
Chr15:51568887..57380584 [GRCh37]
Chr15:49356179..55167876 [NCBI36]
Chr15:15q21.2-21.3
pathogenic
NM_006154.4(NEDD4):c.120-6del deletion not specified [RCV000202979] Chr15:55951595 [GRCh38]
Chr15:56243793 [GRCh37]
Chr15:15q21.3
benign
GRCh37/hg19 15q21.3-22.2(chr15:54713558-62769295)x1 copy number loss See cases [RCV000446622] Chr15:54713558..62769295 [GRCh37]
Chr15:15q21.3-22.2
pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3
pathogenic
GRCh37/hg19 15q21.2-21.3(chr15:50727285-57603305)x3 copy number gain not provided [RCV000683691] Chr15:50727285..57603305 [GRCh37]
Chr15:15q21.2-21.3
pathogenic
GRCh37/hg19 15q21.3(chr15:56132824-56162466)x1 copy number loss not provided [RCV000738797] Chr15:56132824..56162466 [GRCh37]
Chr15:15q21.3
benign
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
NM_006154.4(NEDD4):c.1119G>A (p.Thr373=) single nucleotide variant not provided [RCV000940677] Chr15:55852451 [GRCh38]
Chr15:56144649 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.2297A>G (p.Lys766Arg) single nucleotide variant not provided [RCV000951322] Chr15:55834252 [GRCh38]
Chr15:56126450 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.291+9189T>C single nucleotide variant not provided [RCV000965984] Chr15:55915457 [GRCh38]
Chr15:56207655 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.1139C>T (p.Thr380Ile) single nucleotide variant not provided [RCV000891584] Chr15:55852431 [GRCh38]
Chr15:56144629 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.291+9166G>C single nucleotide variant not provided [RCV000881841] Chr15:55915480 [GRCh38]
Chr15:56207678 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.291+9332T>C single nucleotide variant not provided [RCV000968713] Chr15:55915314 [GRCh38]
Chr15:56207512 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.1953G>C (p.Leu651=) single nucleotide variant not provided [RCV000925192] Chr15:55840613 [GRCh38]
Chr15:56132811 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.291+8009C>A single nucleotide variant not provided [RCV000879872] Chr15:55916637 [GRCh38]
Chr15:56208835 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.291+7901C>A single nucleotide variant not provided [RCV000971407] Chr15:55916745 [GRCh38]
Chr15:56208943 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.291+7895G>A single nucleotide variant not provided [RCV000926790] Chr15:55916751 [GRCh38]
Chr15:56208949 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.291+8022G>C single nucleotide variant not provided [RCV000882268] Chr15:55916624 [GRCh38]
Chr15:56208822 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.1137C>T (p.Pro379=) single nucleotide variant not provided [RCV000923901] Chr15:55852433 [GRCh38]
Chr15:56144631 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.1026+9T>C single nucleotide variant not provided [RCV000898478] Chr15:55856122 [GRCh38]
Chr15:56148320 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.291+8310G>A single nucleotide variant not provided [RCV000960951] Chr15:55916336 [GRCh38]
Chr15:56208534 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.2355G>A (p.Val785=) single nucleotide variant not provided [RCV000895240] Chr15:55834113 [GRCh38]
Chr15:56126311 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.505G>C (p.Glu169Gln) single nucleotide variant not provided [RCV000895241] Chr15:55869581 [GRCh38]
Chr15:56161779 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.306C>T (p.Phe102=) single nucleotide variant not provided [RCV000980325] Chr15:55873994 [GRCh38]
Chr15:56166192 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.861G>A (p.Pro287=) single nucleotide variant not provided [RCV000914031] Chr15:55860506 [GRCh38]
Chr15:56152704 [GRCh37]
Chr15:15q21.3
likely benign
GRCh37/hg19 15q21.1-22.2(chr15:48000433-60747551)x3 copy number gain not provided [RCV000845891] Chr15:48000433..60747551 [GRCh37]
Chr15:15q21.1-22.2
pathogenic
NM_006154.4(NEDD4):c.291+8732T>A single nucleotide variant not provided [RCV000962376] Chr15:55915914 [GRCh38]
Chr15:56208112 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.1287C>A (p.Val429=) single nucleotide variant not provided [RCV000897090] Chr15:55850602 [GRCh38]
Chr15:56142800 [GRCh37]
Chr15:15q21.3
likely benign
GRCh37/hg19 15q21.1-21.3(chr15:49031132-56740397)x3 copy number gain not provided [RCV000849275] Chr15:49031132..56740397 [GRCh37]
Chr15:15q21.1-21.3
pathogenic
NM_006154.4(NEDD4):c.291+9254A>G single nucleotide variant not provided [RCV000902679] Chr15:55915392 [GRCh38]
Chr15:56207590 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.291+8099G>A single nucleotide variant not provided [RCV000953561] Chr15:55916547 [GRCh38]
Chr15:56208745 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.2528-3T>C single nucleotide variant not provided [RCV000900661] Chr15:55830589 [GRCh38]
Chr15:56122787 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.1484-6C>T single nucleotide variant not provided [RCV000886879] Chr15:55848436 [GRCh38]
Chr15:56140634 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.291+8666G>A single nucleotide variant not provided [RCV000964536] Chr15:55915980 [GRCh38]
Chr15:56208178 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.2496G>A (p.Arg832=) single nucleotide variant not provided [RCV000897880] Chr15:55833039 [GRCh38]
Chr15:56125237 [GRCh37]
Chr15:15q21.3
likely benign
NM_006154.4(NEDD4):c.1236G>A (p.Val412=) single nucleotide variant not provided [RCV000931544] Chr15:55850653 [GRCh38]
Chr15:56142851 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.291+8736C>T single nucleotide variant not provided [RCV000957277] Chr15:55915910 [GRCh38]
Chr15:56208108 [GRCh37]
Chr15:15q21.3
benign
NM_006154.4(NEDD4):c.291+8368T>A single nucleotide variant not provided [RCV000957278] Chr15:55916278 [GRCh38]
Chr15:56208476 [GRCh37]
Chr15:15q21.3
benign
GRCh37/hg19 15q21.3(chr15:56186664-56370552)x1 copy number loss not provided [RCV001006696] Chr15:56186664..56370552 [GRCh37]
Chr15:15q21.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7727 AgrOrtholog
COSMIC NEDD4 COSMIC
Ensembl Genes ENSG00000069869 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000345530 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000410613 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000421047 UniProtKB/TrEMBL
  ENSP00000422455 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000422705 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000424471 UniProtKB/TrEMBL
  ENSP00000424827 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000426051 UniProtKB/TrEMBL
  ENSP00000498181 UniProtKB/TrEMBL
Ensembl Transcript ENST00000338963 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000435532 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000502612 UniProtKB/TrEMBL
  ENST00000503468 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000506154 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000507063 UniProtKB/TrEMBL
  ENST00000508342 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000508871 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000648451 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000069869 GTEx
HGNC ID HGNC:7727 ENTREZGENE
Human Proteome Map NEDD4 Human Proteome Map
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4734 UniProtKB/Swiss-Prot
NCBI Gene 4734 ENTREZGENE
OMIM 602278 OMIM
Pfam HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31533 PharmGKB
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HECTc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56204 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.1565 ENTREZGENE
UniProt A0A024R5S9_HUMAN UniProtKB/TrEMBL
  A0A3B3IUC1_HUMAN UniProtKB/TrEMBL
  H0Y8H4_HUMAN UniProtKB/TrEMBL
  H0Y8X6_HUMAN UniProtKB/TrEMBL
  H0Y9L1_HUMAN UniProtKB/TrEMBL
  H0YA37_HUMAN UniProtKB/TrEMBL
  NEDD4_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1KY35 UniProtKB/Swiss-Prot
  A6ND72 UniProtKB/Swiss-Prot
  A7MD29 UniProtKB/Swiss-Prot
  B4E2R7 UniProtKB/Swiss-Prot
  B7ZM59 UniProtKB/Swiss-Prot
  B7ZM60 UniProtKB/Swiss-Prot
  B9EGN5 UniProtKB/Swiss-Prot
  D6RF89 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 NEDD4  NEDD4 E3 ubiquitin protein ligase    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase  Symbol and/or name change 5135510 APPROVED
2012-03-01 NEDD4  neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase  NEDD4  neural precursor cell expressed, developmentally down-regulated 4  Symbol and/or name change 5135510 APPROVED