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Gene: PTGIS (prostaglandin I2 synthase) Homo sapiens
Symbol: PTGIS
Name: prostaglandin I2 synthase
Description: Exhibits heme binding activity and prostaglandin-I synthase activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of peroxisome proliferator activated receptor signaling pathway; and regulation of cellular biosynthetic process. Localizes to the caveola; endoplasmic reticulum; and nucleus. Implicated in essential hypertension and hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CYP8; CYP8A1; cytochrome P450, family 8, subfamily A, polypeptide 1; MGC126858; MGC126860; PGIS; prostacyclin synthase; prostaglandin I2 (prostacyclin) synthase; PTGI
Mus musculus (house mouse) : Ptgis (prostaglandin I2 (prostacyclin) synthase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptgis (prostaglandin I2 synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgis (prostaglandin I2 synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGIS (prostaglandin I2 synthase)
Canis lupus familiaris (dog) : PTGIS (prostaglandin I2 synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgis (prostaglandin I2 synthase)
Sus scrofa (pig) : PTGIS (prostaglandin I2 synthase)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BP29_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382049,503,874 - 49,568,137 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372048,120,411 - 48,184,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362047,553,818 - 47,618,114 (-)NCBINCBI36hg18NCBI36
Build 342047,553,820 - 47,618,114NCBI
Celera2044,825,044 - 44,889,311 (-)NCBI
Cytogenetic Map20q13.13NCBI
HuRef2044,868,991 - 44,933,099 (-)NCBIHuRef
CHM1_12048,024,824 - 48,089,470 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTGIS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736622
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.