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Gene: FN1 (fibronectin 1) Homo sapiens
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Symbol: FN1
Name: fibronectin 1
Description: Exhibits several functions, including chaperone binding activity; disordered domain specific binding activity; and protein C-terminus binding activity. Involved in several processes, including integrin activation; negative regulation of transforming growth factor-beta secretion; and positive regulation of substrate-dependent cell migration, cell attachment to substrate. Localizes to several cellular components, including the endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; and fibrinogen complex. Implicated in membranoproliferative glomerulonephritis. Biomarker of diabetes mellitus; end stage renal failure; glomerulonephritis (multiple); osteoarthritis; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CIG; cold-insoluble globulin; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; ED-B; fibronectin; FINC; FN; FNZ; GFND; GFND2; LETS; migration-stimulating factor; MSF; SMDCF
Orthologs:
Mus musculus (house mouse) : Fn1 (fibronectin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fn1 (fibronectin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fn1 (fibronectin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FN1 (fibronectin 1)
Canis lupus familiaris (dog) : FN1 (fibronectin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fn1 (fibronectin 1)
Sus scrofa (pig) : FN1 (fibronectin 1)
Chlorocebus sabaeus (African green monkey) : FN1 (fibronectin 1)
Heterocephalus glaber (naked mole-rat) : Fn1 (fibronectin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2215,360,440 - 215,436,073 (-)Ensembl
GRCh382215,360,440 - 215,436,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372216,225,177 - 216,300,890 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,933,422 - 216,009,036 (-)NCBINCBI36hg18NCBI36
Build 342216,050,686 - 216,126,297NCBI
Celera2209,994,808 - 210,070,377 (-)NCBI
Cytogenetic Map2q35NCBI
HuRef2208,082,209 - 208,158,070 (-)NCBIHuRef
CHM1_12216,231,063 - 216,306,652 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

Nucleotide Sequences