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Gene: Npr2 (natriuretic peptide receptor 2) Mus musculus
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Symbol: Npr2
Name: natriuretic peptide receptor 2
CRRD ID: 736630
Description: Exhibits guanylate cyclase activity; identical protein binding activity; and natriuretic peptide receptor activity. Involved in several processes, including bone development; negative regulation of meiotic cell cycle; and negative regulation of oocyte maturation. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Used to study achondroplasia; acromesomelic dysplasia, Maroteaux type; and bone development disease. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2); PARTICIPATES IN C-type natriuretic peptide signaling pathway; purine metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ANP-B; ANPR-B; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor type B; c; cn; GC-B; GC-B2; GC-B3; guanylate cyclase B; guanylyl cyclase-B; mNPR-B; natriuretic peptide receptor B type; Nppb receptor; NPR-B; pw; pwe
Orthologs:
Homo sapiens (human) : NPR2 (natriuretic peptide receptor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Npr2 (natriuretic peptide receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr2 (natriuretic peptide receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR2 (natriuretic peptide receptor 2)
Canis lupus familiaris (dog) : NPR2 (natriuretic peptide receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr2 (natriuretic peptide receptor 2)
Sus scrofa (pig) : NPR2 (natriuretic peptide receptor 2)
Chlorocebus sabaeus (African green monkey) : NPR2 (natriuretic peptide receptor 2)
Heterocephalus glaber (naked mole-rat) : Npr2 (natriuretic peptide receptor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl443,631,935 - 43,651,244 (+)EnsemblGRCm38mm10GRCm38
GRCm38443,629,015 - 43,651,437 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37443,644,807 - 43,664,116 (+)NCBIGRCm37mm9NCBIm37
MGSCv36443,653,035 - 43,672,344 (+)NCBImm8
Celera443,666,379 - 43,685,849 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Npr2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736630
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.