Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Npr2 (natriuretic peptide receptor 2) Mus musculus
Symbol: Npr2
Name: natriuretic peptide receptor 2
CRRD ID: 736630
Description: Exhibits guanylate cyclase activity; identical protein binding activity; and natriuretic peptide receptor activity. Involved in several processes, including bone development; negative regulation of meiotic cell cycle; and negative regulation of oocyte maturation. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Used to study achondroplasia; acromesomelic dysplasia, Maroteaux type; and bone development disease. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2); PARTICIPATES IN C-type natriuretic peptide signaling pathway; purine metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ANP-B; ANPR-B; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor type B; c; cn; GC-B; GC-B2; GC-B3; guanylate cyclase B; guanylyl cyclase-B; mNPR-B; natriuretic peptide receptor B type; Nppb receptor; NPR-B; pw; pwe
Homo sapiens (human) : NPR2 (natriuretic peptide receptor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Npr2 (natriuretic peptide receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr2 (natriuretic peptide receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR2 (natriuretic peptide receptor 2)
Canis lupus familiaris (dog) : NPR2 (natriuretic peptide receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr2 (natriuretic peptide receptor 2)
Sus scrofa (pig) : NPR2 (natriuretic peptide receptor 2)
Chlorocebus sabaeus (African green monkey) : NPR2 (natriuretic peptide receptor 2)
Heterocephalus glaber (naked mole-rat) : Npr2 (natriuretic peptide receptor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl443,631,935 - 43,651,244 (+)EnsemblGRCm38mm10GRCm38
GRCm38443,629,015 - 43,651,437 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37443,644,807 - 43,664,116 (+)NCBIGRCm37mm9NCBIm37
MGSCv36443,653,035 - 43,672,344 (+)NCBImm8
Celera443,666,379 - 43,685,849 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Npr2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736630
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.