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Gene: ITGB1 (integrin subunit beta 1) Homo sapiens
Symbol: ITGB1
Name: integrin subunit beta 1
Description: Exhibits several functions, including collagen binding activity involved in cell-matrix adhesion; fibronectin binding activity; and protein heterodimerization activity. Contributes to C-X3-C chemokine binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of apoptotic process; and regulation of signal transduction. Localizes to several cellular components, including the focal adhesion; integrin complex; and invadopodium membrane. Colocalizes with the perinuclear region of cytoplasm and ruffle membrane. Biomarker of lung non-small cell carcinoma and lung small cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD29; fibronectin receptor beta subunit; fibronectin receptor subunit beta; FNRB; glycoprotein IIa; GPIIA; integrin beta 1; integrin beta-1; integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); MDF2; MSK12; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLA-BETA; VLAB
Mus musculus (house mouse) : Itgb1 (integrin beta 1 (fibronectin receptor beta))  MGI  Alliance
Rattus norvegicus (Norway rat) : Itgb1 (integrin subunit beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb1 (integrin subunit beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB1 (integrin subunit beta 1)
Canis lupus familiaris (dog) : ITGB1 (integrin subunit beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb1 (integrin subunit beta 1)
Sus scrofa (pig) : ITGB1 (integrin subunit beta 1)
more info ...
Related Pseudogenes: ITGB1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1032,900,318 - 33,005,792 (-)Ensembl
GRCh381032,900,318 - 32,958,230 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371033,189,246 - 33,247,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361033,229,326 - 33,287,204 (-)NCBINCBI36hg18NCBI36
Build 341033,236,244 - 33,264,492NCBI
Celera1032,954,580 - 33,012,639 (-)NCBI
Cytogenetic Map10p11.22NCBI
HuRef1032,908,756 - 32,966,834 (-)NCBIHuRef
CHM1_11033,190,855 - 33,248,907 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ITGB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736631
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.