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Gene: DBH (dopamine beta-hydroxylase) Homo sapiens
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Symbol: DBH
Name: dopamine beta-hydroxylase
CRRD ID: 736659
Description: Exhibits copper ion binding activity and dopamine beta-monooxygenase activity. Involved in dopamine catabolic process and norepinephrine biosynthetic process. Localizes to several cellular components, including centriolar satellite; endoplasmic reticulum; and secretory granule. Implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Biomarker of Parkinson's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DBM; dopamine beta hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); ORTHYP1
Orthologs:
Mus musculus (house mouse) : Dbh (dopamine beta hydroxylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dbh (dopamine beta-hydroxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dbh (dopamine beta-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : DBH (dopamine beta-hydroxylase)
Canis lupus familiaris (dog) : DBH (dopamine beta-hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dbh (dopamine beta-hydroxylase)
Sus scrofa (pig) : DBH (dopamine beta-hydroxylase)
Chlorocebus sabaeus (African green monkey) : DBH (dopamine beta-hydroxylase)
Heterocephalus glaber (naked mole-rat) : Dbh (dopamine beta-hydroxylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9133,636,363 - 133,659,329 (+)EnsemblGRCh38hg38GRCh38
GRCh389133,636,363 - 133,659,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379136,501,485 - 136,524,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,491,306 - 135,514,287 (+)NCBINCBI36hg18NCBI36
Build 349133,531,038 - 133,554,020NCBI
Celera9107,048,360 - 107,071,346 (+)NCBI
Cytogenetic Map9q34.2NCBI
HuRef9106,002,148 - 106,025,141 (+)NCBIHuRef
CHM1_19136,651,448 - 136,674,425 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DBH
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736659
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.