Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: DBH (dopamine beta-hydroxylase) Homo sapiens
Analyze
Symbol: DBH
Name: dopamine beta-hydroxylase
Description: Exhibits copper ion binding activity and dopamine beta-monooxygenase activity. Involved in dopamine catabolic process and norepinephrine biosynthetic process. Localizes to several cellular components, including the centriolar satellite; endoplasmic reticulum; and secretory granule. Implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Biomarker of Parkinson's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DBM; dopamine beta hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); ORTHYP1
Orthologs:
Mus musculus (house mouse) : Dbh (dopamine beta hydroxylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dbh (dopamine beta-hydroxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dbh (dopamine beta-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : DBH (dopamine beta-hydroxylase)
Canis lupus familiaris (dog) : DBH (dopamine beta-hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dbh (dopamine beta-hydroxylase)
Sus scrofa (pig) : DBH (dopamine beta-hydroxylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,636,363 - 133,659,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379136,501,485 - 136,524,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,491,306 - 135,514,287 (+)NCBINCBI36hg18NCBI36
Build 349133,531,038 - 133,554,020NCBI
Celera9107,048,360 - 107,071,346 (+)NCBI
Cytogenetic Map9q34.2NCBI
HuRef9106,002,148 - 106,025,141 (+)NCBIHuRef
CHM1_19136,651,448 - 136,674,425 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DBH
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736659
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.