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Gene: Mecp2 (methyl CpG binding protein 2) Mus musculus
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Symbol: Mecp2
Name: methyl CpG binding protein 2
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding activity; and nucleic acid binding activity. Involved in several processes, including learning or memory; nervous system development; and regulation of gene expression. Localizes to the cytosol and nucleus. Colocalizes with the heterochromatin. Used to study Rett syndrome. Human ortholog(s) of this gene implicated in Rett syndrome; X-linked intellectual disability-psychosis-macroorchidism syndrome; autistic disorder; and syndromic X-linked intellectual disability Lubs type. Is expressed in several structures, including alimentary system; limb; nervous system; paraxial mesenchyme; and sensory organ. Orthologous to human MECP2 (methyl-CpG binding protein 2); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1500041B07Rik; BB130002; D630021H01Rik; Mbd5; meCp-2 protein; methyl-CpG-binding protein 2; WBP10
Orthologs:
Homo sapiens (human) : MECP2 (methyl-CpG binding protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mecp2 (methyl CpG binding protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mecp2 (methyl-CpG binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MECP2 (methyl-CpG binding protein 2)
Canis lupus familiaris (dog) : MECP2 (methyl-CpG binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mecp2 (methyl-CpG binding protein 2)
Sus scrofa (pig) : MECP2 (methyl-CpG binding protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38X74,026,592 - 74,085,690 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X71,272,160 - 71,330,975 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X70,279,550 - 70,338,313 (-)NCBImm8
CeleraX65,278,982 - 65,338,075 (-)NCBICelera
Cytogenetic MapX A7.3NCBI
cM MapX37.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Mecp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736671
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.