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Gene: Mecp2 (methyl CpG binding protein 2) Mus musculus
Symbol: Mecp2
Name: methyl CpG binding protein 2
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding activity; and nucleic acid binding activity. Involved in several processes, including learning or memory; nervous system development; and regulation of gene expression. Localizes to the cytosol and nucleus. Colocalizes with the heterochromatin. Used to study Rett syndrome. Human ortholog(s) of this gene implicated in Rett syndrome; X-linked intellectual disability-psychosis-macroorchidism syndrome; autistic disorder; and syndromic X-linked intellectual disability Lubs type. Is expressed in several structures, including alimentary system; limb; nervous system; paraxial mesenchyme; and sensory organ. Orthologous to human MECP2 (methyl-CpG binding protein 2); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1500041B07Rik; BB130002; D630021H01Rik; Mbd5; meCp-2 protein; methyl-CpG-binding protein 2; WBP10
Homo sapiens (human) : MECP2 (methyl-CpG binding protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mecp2 (methyl CpG binding protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mecp2 (methyl-CpG binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MECP2 (methyl-CpG binding protein 2)
Canis lupus familiaris (dog) : MECP2 (methyl-CpG binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mecp2 (methyl-CpG binding protein 2)
Sus scrofa (pig) : MECP2 (methyl-CpG binding protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38X74,026,592 - 74,085,690 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X71,272,160 - 71,330,975 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X70,279,550 - 70,338,313 (-)NCBImm8
CeleraX65,278,982 - 65,338,075 (-)NCBICelera
Cytogenetic MapX A7.3NCBI
cM MapX37.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mecp2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736671
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.