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Gene: PTGS1 (prostaglandin-endoperoxide synthase 1) Homo sapiens
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Symbol: PTGS1
Name: prostaglandin-endoperoxide synthase 1
Description: Exhibits prostaglandin-endoperoxide synthase activity. Involved in cyclooxygenase pathway. Localizes to the Golgi apparatus. Biomarker of several diseases, including Creutzfeldt-Jakob disease; bipolar disorder; brain ischemia; female reproductive organ cancer (multiple); and glioblastoma multiforme.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: COX-1; COX1; COX3; cyclooxygenase-1; PCOX1; PES-1; PGG/HS; PGH synthase 1; PGHS-1; PGHS1; PHS 1; PHS1; prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin H2 synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGHS
Orthologs:
Mus musculus (house mouse) : Ptgs1 (prostaglandin-endoperoxide synthase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptgs1 (prostaglandin-endoperoxide synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Canis lupus familiaris (dog) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
Sus scrofa (pig) : PTGS1 (prostaglandin-endoperoxide synthase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389122,369,906 - 122,395,703 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379125,132,809 - 125,157,982 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,173,050 - 124,197,802 (+)NCBINCBI36hg18NCBI36
Build 349122,212,782 - 122,237,535NCBI
Celera995,781,549 - 95,806,298 (+)NCBI
Cytogenetic Map9q33.2NCBI
HuRef994,747,532 - 94,772,698 (+)NCBIHuRef
CHM1_19125,280,871 - 125,306,038 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PTGS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736739
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.