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Gene: YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta) Homo sapiens
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Symbol: YWHAZ
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Description: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 14-3-3 delta; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 zeta; 14-3-3-zeta; epididymis luminal protein 4; epididymis secretory protein Li 3; epididymis secretory protein Li 93; HEL-S-3; HEL-S-93; HEL4; KCIP-1; MGC111427; MGC126532; MGC138156; phospholipase A2; POPCHAS; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; YWHAD
Orthologs:
Related Pseudogenes: YWHAZP1   YWHAZP2   YWHAZP3   YWHAZP4   YWHAZP5   YWHAZP6   YWHAZP7   YWHAZP8   YWHAZP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388100,918,576 - 100,954,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378101,930,804 - 101,965,717 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368102,000,090 - 102,034,745 (-)NCBINCBI36hg18NCBI36
Build 348102,000,089 - 102,033,447NCBI
Celera898,115,836 - 98,150,667 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef897,128,746 - 97,163,575 (-)NCBIHuRef
CHM1_18101,971,677 - 102,006,519 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on YWHAZ
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736756
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-06-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.