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Gene: CYP1B1 (cytochrome P450 family 1 subfamily B member 1) Homo sapiens
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Symbol: CYP1B1
Name: cytochrome P450 family 1 subfamily B member 1
Description: Exhibits estrogen 16-alpha-hydroxylase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including arachidonic acid metabolic process; estrogen metabolic process; and retinoid metabolic process. Predicted to localize to the mitochondrion. Implicated in Peters anomaly; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Biomarker of urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aryl hydrocarbon hydroxylase; ASGD6; CP1B; CYPIB1; cytochrome P450 1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome p450, subfamily 1b, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); dioxin-inducible cytochrome p450; flavoprotein-linked monooxygenase; GLC3A; hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P4501B1; xenobiotic monooxygenase
Orthologs:
Mus musculus (house mouse) : Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102009223 (cytochrome P450 1B1)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100989599 (cytochrome P450 1B1)
Canis lupus familiaris (dog) : CYP1B1 (cytochrome P450 family 1 subfamily B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101970101 (cytochrome P450 1B1)
Sus scrofa (pig) : LOC100625479 (cytochrome P450 1B1)
Chlorocebus sabaeus (green monkey) : CYP1B1 (cytochrome P450 family 1 subfamily B member 1)
Heterocephalus glaber (naked mole-rat) : LOC101701066 (cytochrome P450 1B1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl238,066,973 - 38,109,902 (-)Ensembl
GRCh38238,067,603 - 38,076,181 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37238,294,746 - 38,303,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36238,148,250 - 38,156,796 (-)NCBINCBI36hg18NCBI36
Build 34238,206,396 - 38,214,943NCBI
Celera238,135,623 - 38,144,201 (-)NCBI
Cytogenetic Map2p22.2NCBI
HuRef238,034,680 - 38,043,258 (-)NCBIHuRef
CHM1_1238,224,106 - 38,232,684 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

Nucleotide Sequences