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Gene: Pitx3 (paired-like homeodomain transcription factor 3) Mus musculus
Symbol: Pitx3
Name: paired-like homeodomain transcription factor 3
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including lens development in camera-type eye; nervous system development; and positive regulation of transcription by RNA polymerase II. Localizes to nucleus. Is expressed in several structures, including alimentary system; brain; eye; limb; and musculoskeletal system. Used to study Parkinson's disease and anterior segment dysgenesis. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 1; cataract; cataract 11 multiple types; and cataract 9 multiple types. Orthologous to human PITX3 (paired like homeodomain 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ak; aphakia; homeobox protein PITX3; pituitary homeobox 3; Pituitary homeobox 3 (Homeobox protein PITX3); Ptx3
Homo sapiens (human) : PITX3 (paired like homeodomain 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pitx3 (paired-like homeodomain 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pitx3 (paired like homeodomain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PITX3 (paired like homeodomain 3)
Canis lupus familiaris (dog) : PITX3 (paired like homeodomain 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pitx3 (paired like homeodomain 3)
Sus scrofa (pig) : PITX3 (paired like homeodomain 3)
Chlorocebus sabaeus (African green monkey) : PITX3 (paired like homeodomain 3)
Heterocephalus glaber (naked mole-rat) : Pitx3 (paired like homeodomain 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1946,135,685 - 46,148,326 (-)EnsemblGRCm38mm10GRCm38
GRCm381946,135,281 - 46,148,325 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371946,210,175 - 46,222,815 (-)NCBIGRCm37mm9NCBIm37
MGSCv361946,188,996 - 46,201,636 (-)NCBImm8
Celera1946,899,486 - 46,912,129 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pitx3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736766
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.