Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pitx3 (paired-like homeodomain transcription factor 3) Mus musculus
Analyze
Symbol: Pitx3
Name: paired-like homeodomain transcription factor 3
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including lens development in camera-type eye; nervous system development; and positive regulation of transcription by RNA polymerase II. Localizes to nucleus. Is expressed in several structures, including alimentary system; brain; eye; limb; and musculoskeletal system. Used to study Parkinson's disease and anterior segment dysgenesis. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 1; cataract; cataract 11 multiple types; and cataract 9 multiple types. Orthologous to human PITX3 (paired like homeodomain 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ak; aphakia; homeobox protein PITX3; pituitary homeobox 3; Pituitary homeobox 3 (Homeobox protein PITX3); Ptx3
Orthologs:
Homo sapiens (human) : PITX3 (paired like homeodomain 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pitx3 (paired-like homeodomain 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pitx3 (paired like homeodomain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PITX3 (paired like homeodomain 3)
Canis lupus familiaris (dog) : PITX3 (paired like homeodomain 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pitx3 (paired like homeodomain 3)
Sus scrofa (pig) : PITX3 (paired like homeodomain 3)
Chlorocebus sabaeus (African green monkey) : PITX3 (paired like homeodomain 3)
Heterocephalus glaber (naked mole-rat) : Pitx3 (paired like homeodomain 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1946,135,685 - 46,148,326 (-)EnsemblGRCm38mm10GRCm38
GRCm381946,135,281 - 46,148,325 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371946,210,175 - 46,222,815 (-)NCBIGRCm37mm9NCBIm37
MGSCv361946,188,996 - 46,201,636 (-)NCBImm8
Celera1946,899,486 - 46,912,129 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pitx3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736766
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.