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Gene: Grm5 (glutamate receptor, metabotropic 5) Mus musculus
Symbol: Grm5
Name: glutamate receptor, metabotropic 5
Description: Exhibits G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and modulation of chemical synaptic transmission. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; neuron projection; and plasma membrane. Used to study schizophrenia. Is expressed in central nervous system and retina. Orthologous to human GRM5 (glutamate metabotropic receptor 5); PARTICIPATES IN glutamate signaling pathway; Huntington's disease pathway; long term depression; INTERACTS WITH (S)-nicotine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6430542K11Rik; AI850523; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member E; Glu5R; Gprc1e; metabotropic glutamate receptor 5; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; mGluR5; mGluR5b
Homo sapiens (human) : GRM5 (glutamate metabotropic receptor 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grm5 (glutamate metabotropic receptor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grm5 (glutamate metabotropic receptor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GRM5 (glutamate metabotropic receptor 5)
Canis lupus familiaris (dog) : GRM5 (glutamate metabotropic receptor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grm5 (glutamate metabotropic receptor 5)
Sus scrofa (pig) : GRM5 (glutamate metabotropic receptor 5)
Chlorocebus sabaeus (green monkey) : GRM5 (glutamate metabotropic receptor 5)
Heterocephalus glaber (naked mole-rat) : Grm5 (glutamate metabotropic receptor 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl787,584,168 - 88,134,907 (+)Ensembl
GRCm38787,583,981 - 88,135,063 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37794,732,678 - 95,283,573 (+)NCBIGRCm37mm9NCBIm37
MGSCv36787,459,538 - 88,009,526 (+)NCBImm8
Celera784,945,210 - 85,487,922 (+)NCBICelera
Cytogenetic Map7D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Grm5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736778
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.