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Gene: Pemt (phosphatidylethanolamine N-methyltransferase) Mus musculus
Symbol: Pemt
Name: phosphatidylethanolamine N-methyltransferase
Description: Exhibits S-adenosylmethionine-dependent methyltransferase activity. Involved in blastocyst hatching; positive regulation of cold-induced thermogenesis; and sphingomyelin biosynthetic process. Localizes to endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; early conceptus; liver; lung; and secondary oocyte. Orthologous to human PEMT (phosphatidylethanolamine N-methyltransferase); PARTICIPATES IN choline metabolic pathway; glycerophospholipid metabolic pathway; remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependent; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI255394; PEAMT; Pempt; Pempt2; PEMT2; phospholipid methyltransferase; PLMT
Homo sapiens (human) : PEMT (phosphatidylethanolamine N-methyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pemt (phosphatidylethanolamine N-methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pemt (phosphatidylethanolamine N-methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : PEMT (phosphatidylethanolamine N-methyltransferase)
Canis lupus familiaris (dog) : PEMT (phosphatidylethanolamine N-methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pemt (phosphatidylethanolamine N-methyltransferase)
Sus scrofa (pig) : PEMT (phosphatidylethanolamine N-methyltransferase)
Chlorocebus sabaeus (African green monkey) : PEMT (phosphatidylethanolamine N-methyltransferase)
Heterocephalus glaber (naked mole-rat) : Pemt (phosphatidylethanolamine N-methyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1159,970,614 - 60,046,489 (-)EnsemblGRCm38mm10GRCm38
GRCm381159,970,614 - 60,046,561 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371159,784,119 - 59,850,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv361159,786,812 - 59,853,034 (-)NCBImm8
MGSCv361160,507,197 - 60,573,128 (-)NCBImm8
Cytogenetic Map11B1.3NCBI
cM Map1137.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pemt
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736786
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.