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Gene: DRD2 (dopamine receptor D2) Homo sapiens
Symbol: DRD2
Name: dopamine receptor D2
Description: Exhibits dopamine neurotransmitter receptor activity, coupled via Gi/Go; drug binding activity; and identical protein binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; arachidonic acid secretion; and regulation of protein secretion. Localizes to the ciliary membrane; integral component of plasma membrane; and non-motile cilium. Implicated in several diseases, including brain disease (multiple); end stage renal failure; mental depression; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D(2) dopamine receptor; D2DR; D2R; dopamine D2 receptor; dopamine receptor 2; dopamine receptor D2 isoform; seven transmembrane helix receptor
Mus musculus (house mouse) : Drd2 (dopamine receptor D2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Drd2 (dopamine receptor D2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd2 (dopamine receptor D2)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD2 (dopamine receptor D2)
Canis lupus familiaris (dog) : DRD2 (dopamine receptor D2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd2 (dopamine receptor D2)
Sus scrofa (pig) : DRD2 (dopamine receptor D2)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   SCL20_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: A frequently studied SNP, known as TaqI DRD2 (rs1800497), was originally associated with the DRD2 gene (GeneID 1813) but was later found to be located within exon 8 of the adjacent gene, ANKK1 (GeneID 255239). The location of rs1800497 is not always specified within publications. Publications may be associated with either locus or with both loci in order to point out the relationship of rs1800497 to both loci. [13 Feb 2013]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811113,409,595 - 113,475,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711113,280,317 - 113,346,413 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,785,527 - 112,851,091 (-)NCBINCBI36hg18NCBI36
Build 3411112,785,527 - 112,851,103NCBI
Celera11110,433,249 - 110,498,937 (-)NCBI
Cytogenetic Map11q23.2NCBI
HuRef11109,208,766 - 109,274,420 (-)NCBIHuRef
CHM1_111113,163,302 - 113,228,980 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DRD2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736796
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.