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Gene: SHH (sonic hedgehog signaling molecule) Homo sapiens
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Symbol: SHH
Name: sonic hedgehog signaling molecule
CRRD ID: 736829
Description: Exhibits calcium ion binding activity; patched binding activity; and zinc ion binding activity. Involved in several processes, including animal organ development; positive regulation of sclerotome development; and positive regulation of smoothened signaling pathway. Localizes to extracellular space. Implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Biomarker of autism spectrum disorder; biliary atresia; glomerulonephritis (multiple); multiple sclerosis (multiple); and temporal lobe epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HHG1; HLP3; HPE3; MCOPCB5; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; SMMCI; sonic hedgehog; sonic hedgehog homolog; sonic hedgehog protein; TPT; TPTPS
Orthologs:
Mus musculus (house mouse) : Shh (sonic hedgehog)  MGI  Alliance
Rattus norvegicus (Norway rat) : Shh (sonic hedgehog signaling molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shh (sonic hedgehog signaling molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : SHH (sonic hedgehog signaling molecule)
Canis lupus familiaris (dog) : SHH (sonic hedgehog signaling molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shh (sonic hedgehog signaling molecule)
Sus scrofa (pig) : SHH (sonic hedgehog signaling molecule)
Chlorocebus sabaeus (African green monkey) : SHH (sonic hedgehog signaling molecule)
Heterocephalus glaber (naked mole-rat) : Shh (sonic hedgehog signaling molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7155,799,980 - 155,812,463 (-)EnsemblGRCh38hg38GRCh38
GRCh387155,799,980 - 155,812,463 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377155,595,558 - 155,604,967 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367155,288,319 - 155,297,728 (-)NCBINCBI36hg18NCBI36
Build 347155,095,033 - 155,104,443NCBI
Celera7150,021,217 - 150,030,626 (-)NCBI
Cytogenetic Map7q36.3NCBI
HuRef7149,327,101 - 149,336,513 (-)NCBIHuRef
CHM1_17155,601,138 - 155,613,409 (-)NCBICHM1_1
CRA_TCAGchr7v27154,827,119 - 154,836,528 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

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RNA-SEQ Expression

Sequence

Nucleotide Sequences
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External Database Links
Nomenclature History
 
More on SHH
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736829
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.