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Gene: SHH (sonic hedgehog signaling molecule) Homo sapiens
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Symbol: SHH
Name: sonic hedgehog signaling molecule
Description: Exhibits calcium ion binding activity; patched binding activity; and zinc ion binding activity. Involved in several processes, including animal organ development; positive regulation of sclerotome development; and positive regulation of smoothened signaling pathway. Localizes to the extracellular space. Implicated in Hirschsprung's disease; basal cell carcinoma; holoprosencephaly (multiple); middle cerebral artery infarction; and polydactyly. Biomarker of autism spectrum disorder; biliary atresia; glomerulonephritis (multiple); multiple sclerosis (multiple); and temporal lobe epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HHG1; HLP3; HPE3; MCOPCB5; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; SMMCI; sonic hedgehog; sonic hedgehog homolog; sonic hedgehog protein; TPT; TPTPS
Orthologs:
Mus musculus (house mouse) : Shh (sonic hedgehog)  MGI  Alliance
Rattus norvegicus (Norway rat) : Shh (sonic hedgehog signaling molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shh (sonic hedgehog signaling molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : SHH (sonic hedgehog signaling molecule)
Canis lupus familiaris (dog) : SHH (sonic hedgehog signaling molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shh (sonic hedgehog signaling molecule)
Sus scrofa (pig) : SHH (sonic hedgehog signaling molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,799,980 - 155,812,463 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377155,595,558 - 155,604,967 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367155,288,319 - 155,297,728 (-)NCBINCBI36hg18NCBI36
Build 347155,095,033 - 155,104,443NCBI
Celera7150,021,217 - 150,030,626 (-)NCBI
Cytogenetic Map7q36.3NCBI
HuRef7149,327,101 - 149,336,513 (-)NCBIHuRef
CHM1_17155,601,138 - 155,613,409 (-)NCBICHM1_1
CRA_TCAGchr7v27154,827,119 - 154,836,528 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SHH
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736829
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.