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Gene: EGF (epidermal growth factor) Homo sapiens
Symbol: EGF
Name: epidermal growth factor
Description: Exhibits Ras guanyl-nucleotide exchange factor activity and growth factor activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of macromolecule metabolic process; and regulation of cellular protein localization. Localizes to the extracellular exosome. Implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); lung cancer (multiple); malignant glioma (multiple); and primary hypomagnesemia (multiple). Biomarker of several diseases, including acute kidney failure; endocrine gland cancer (multiple); inclusion body myopathy with Paget disease of bone and frontotemporal dementia; lupus nephritis; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta-urogastrone; HOMG4; pro-epidermal growth factor; URG
Mus musculus (house mouse) : Egf (epidermal growth factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Egf (epidermal growth factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egf (epidermal growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : EGF (epidermal growth factor)
Canis lupus familiaris (dog) : EGF (epidermal growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egf (epidermal growth factor)
Sus scrofa (pig) : EGF (epidermal growth factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384109,912,883 - 110,013,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374110,834,040 - 110,934,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,053,499 - 111,152,868 (+)NCBINCBI36hg18NCBI36
Build 344111,191,653 - 111,291,023NCBI
Celera4108,127,771 - 108,227,842 (+)NCBI
Cytogenetic Map4q25NCBI
HuRef4106,566,131 - 106,666,223 (+)NCBIHuRef
CHM1_14110,810,552 - 110,910,746 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EGF
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736832
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.