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Gene: EGF (epidermal growth factor) Homo sapiens
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Symbol: EGF
Name: epidermal growth factor
Description: Exhibits Ras guanyl-nucleotide exchange factor activity and growth factor activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of macromolecule metabolic process; and regulation of cellular protein localization. Localizes to the extracellular exosome. Implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); lung cancer (multiple); malignant glioma (multiple); and primary hypomagnesemia (multiple). Biomarker of several diseases, including acute kidney failure; endocrine gland cancer (multiple); inclusion body myopathy with Paget disease of bone and frontotemporal dementia; lupus nephritis; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta-urogastrone; HOMG4; pro-epidermal growth factor; URG
Orthologs:
Mus musculus (house mouse) : Egf (epidermal growth factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Egf (epidermal growth factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egf (epidermal growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : EGF (epidermal growth factor)
Canis lupus familiaris (dog) : EGF (epidermal growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egf (epidermal growth factor)
Sus scrofa (pig) : EGF (epidermal growth factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384109,912,883 - 110,013,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374110,834,040 - 110,934,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,053,499 - 111,152,868 (+)NCBINCBI36hg18NCBI36
Build 344111,191,653 - 111,291,023NCBI
Celera4108,127,771 - 108,227,842 (+)NCBI
Cytogenetic Map4q25NCBI
HuRef4106,566,131 - 106,666,223 (+)NCBIHuRef
CHM1_14110,810,552 - 110,910,746 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on EGF
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736832
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.