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Gene: HTR2C (5-hydroxytryptamine receptor 2C) Homo sapiens
Symbol: HTR2C
Name: 5-hydroxytryptamine receptor 2C
CRRD ID: 736842
Description: Exhibits several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity. Involved in several processes, including cGMP-mediated signaling; phospholipase C-activating serotonin receptor signaling pathway; and positive regulation of phosphate metabolic process. Localizes to G protein-coupled serotonin receptor complex and integral component of plasma membrane. Implicated in bipolar disorder; obesity; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor-1c; 5HTR2C; HTR1C; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; serotonin receptor 2C
Mus musculus (house mouse) : Htr2c (5-hydroxytryptamine (serotonin) receptor 2C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Htr2c (5-hydroxytryptamine receptor 2C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htr2c (5-hydroxytryptamine receptor 2C)
Pan paniscus (bonobo/pygmy chimpanzee) : HTR2C (5-hydroxytryptamine receptor 2C)
Canis lupus familiaris (dog) : HTR2C (5-hydroxytryptamine receptor 2C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htr2c (5-hydroxytryptamine receptor 2C)
Sus scrofa (pig) : HTR2C (5-hydroxytryptamine receptor 2C)
Chlorocebus sabaeus (African green monkey) : HTR2C (5-hydroxytryptamine receptor 2C)
Heterocephalus glaber (naked mole-rat) : Htr2c (5-hydroxytryptamine receptor 2C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX114,584,078 - 114,910,061 (+)EnsemblGRCh38hg38GRCh38
GRCh38X114,584,078 - 114,910,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X113,818,551 - 114,144,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X113,724,807 - 114,050,880 (+)NCBINCBI36hg18NCBI36
Build 34X113,641,530 - 113,967,604NCBI
CeleraX114,253,715 - 114,579,778 (+)NCBI
Cytogenetic MapXq23NCBI
HuRefX103,403,272 - 103,731,741 (+)NCBIHuRef
CHM1_1X113,729,484 - 114,055,500 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HTR2C
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736842
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.