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Gene: HTR2C (5-hydroxytryptamine receptor 2C) Homo sapiens
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Symbol: HTR2C
Name: 5-hydroxytryptamine receptor 2C
Description: This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor-1c; 5HTR2C; HTR1C; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; serotonin receptor 2C
Orthologs:
Mus musculus (house mouse) : Htr2c (5-hydroxytryptamine (serotonin) receptor 2C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Htr2c (5-hydroxytryptamine receptor 2C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htr2c (5-hydroxytryptamine receptor 2C)
Pan paniscus (bonobo/pygmy chimpanzee) : HTR2C (5-hydroxytryptamine receptor 2C)
Canis lupus familiaris (dog) : HTR2C (5-hydroxytryptamine receptor 2C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htr2c (5-hydroxytryptamine receptor 2C)
Sus scrofa (pig) : HTR2C (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X114,584,078 - 114,910,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X113,818,551 - 114,144,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X113,724,807 - 114,050,880 (+)NCBINCBI36hg18NCBI36
Build 34X113,641,530 - 113,967,604NCBI
CeleraX114,253,715 - 114,579,778 (+)NCBI
Cytogenetic MapXq23NCBI
HuRefX103,403,272 - 103,731,741 (+)NCBIHuRef
CHM1_1X113,729,484 - 114,055,500 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HTR2C
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736842
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.