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Gene: CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) Homo sapiens
Symbol: CHRNA7
Name: cholinergic receptor nicotinic alpha 7 subunit
Description: Exhibits several functions, including acetylcholine binding activity; amyloid-beta binding activity; and postsynaptic neurotransmitter receptor activity. Involved in several processes, including negative regulation of tumor necrosis factor production; regulation of protein metabolic process; and response to nicotine. Localizes to acetylcholine-gated channel complex. Implicated in schizophrenia. Biomarker of Alzheimer's disease and Lewy body dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a7 nicotinic acetylcholine receptor; acetylcholine receptor, nicotinic, alpha 7 (neuronal); alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; cholinergic receptor, nicotinic alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; CHRNA7-2; NACHRA7; neuronal acetylcholine receptor protein, alpha-7 chain; neuronal acetylcholine receptor subunit alpha-7
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1531,923,438 - 32,173,018 (+)EnsemblGRCh38hg38GRCh38
GRCh381532,030,462 - 32,173,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371532,322,686 - 32,462,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,110,018 - 30,248,541 (+)NCBINCBI36hg18NCBI36
Build 341530,110,017 - 30,248,525NCBI
Celera158,162,865 - 8,292,202 (-)NCBI
Cytogenetic Map15q13.3NCBI
HuRef159,499,328 - 9,603,273 (+)NCBIHuRef
CHM1_11532,312,897 - 32,452,812 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CHRNA7
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736847
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.