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Gene: CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) Homo sapiens
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Symbol: CHRNA7
Name: cholinergic receptor nicotinic alpha 7 subunit
Description: Exhibits several functions, including acetylcholine binding activity; amyloid-beta binding activity; and postsynaptic neurotransmitter receptor activity. Involved in several processes, including negative regulation of tumor necrosis factor production; regulation of protein metabolic process; and response to nicotine. Localizes to acetylcholine-gated channel complex. Implicated in schizophrenia. Biomarker of Alzheimer's disease and Lewy body dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a7 nicotinic acetylcholine receptor; acetylcholine receptor, nicotinic, alpha 7 (neuronal); alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; cholinergic receptor, nicotinic alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; CHRNA7-2; NACHRA7; neuronal acetylcholine receptor protein, alpha-7 chain; neuronal acetylcholine receptor subunit alpha-7
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1531,923,438 - 32,173,018 (+)EnsemblGRCh38hg38GRCh38
GRCh381532,030,462 - 32,173,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371532,322,686 - 32,462,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,110,018 - 30,248,541 (+)NCBINCBI36hg18NCBI36
Build 341530,110,017 - 30,248,525NCBI
Celera158,162,865 - 8,292,202 (-)NCBI
Cytogenetic Map15q13.3NCBI
HuRef159,499,328 - 9,603,273 (+)NCBIHuRef
CHM1_11532,312,897 - 32,452,812 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CHRNA7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736847
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.