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Gene: DHFR (dihydrofolate reductase) Homo sapiens
Symbol: DHFR
Name: dihydrofolate reductase
Description: Exhibits anion binding activity; dihydrofolate reductase activity; and nucleic acid binding activity. Involved in several processes, including folic acid-containing compound metabolic process; negative regulation of translation; and tetrahydrobiopterin biosynthetic process. Localizes to mitochondrion. Implicated in acute lymphoblastic leukemia. Biomarker of acute lymphoblastic leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DHFRP1; DYR
Mus musculus (house mouse) : Dhfr (dihydrofolate reductase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dhfr (dihydrofolate reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhfr (dihydrofolate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : DHFR (dihydrofolate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhfr (dihydrofolate reductase)
Sus scrofa (pig) : DHFR (dihydrofolate reductase)
Chlorocebus sabaeus (African green monkey) : DHFR (dihydrofolate reductase)
Heterocephalus glaber (naked mole-rat) : Dhfr (dihydrofolate reductase)
more info ...
Related Pseudogenes: DHFRP1   DHFRP2   DHFRP3   DHFRP5   DHFRP6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl580,626,226 - 80,654,983 (-)EnsemblGRCh38hg38GRCh38
GRCh38580,626,226 - 80,654,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37579,922,045 - 79,950,800 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,957,801 - 79,986,556 (-)NCBINCBI36hg18NCBI36
Build 34579,957,803 - 79,986,572NCBI
Celera575,825,049 - 75,854,857 (-)NCBI
Cytogenetic Map5q14.1NCBI
HuRef575,130,997 - 75,159,721 (-)NCBIHuRef
CHM1_1579,355,281 - 79,384,046 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DHFR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736871
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.