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Gene: GC (GC vitamin D binding protein) Homo sapiens
Symbol: GC
Name: GC vitamin D binding protein
CRRD ID: 736902
Description: Exhibits actin binding activity and calcidiol binding activity. Predicted to be involved in vitamin D metabolic process and vitamin transport. Localizes to blood microparticle and extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Biomarker of several diseases, including autoimmune disease (multiple); dengue disease; diabetic retinopathy; hepatic encephalopathy; and sciatic neuropathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DBP; DBP-maf; DBP/GC; epididymis secretory protein Li 51; gc protein-derived macrophage activating factor; gc-globulin; Gc-MAF; GcMAF; GRD3; group-specific component (vitamin D binding protein); HEL-S-51; VDB; VDBG; VDBP; vitamin D-binding alpha-globulin; vitamin D-binding protein; vitamin D-binding protein-macrophage activating factor
Mus musculus (house mouse) : Gc (vitamin D binding protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gc (GC, vitamin D binding protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gc (GC vitamin D binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : GC (GC vitamin D binding protein)
Canis lupus familiaris (dog) : GC (GC vitamin D binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gc (GC vitamin D binding protein)
Sus scrofa (pig) : GC (GC vitamin D binding protein)
Chlorocebus sabaeus (African green monkey) : GC (GC vitamin D binding protein)
Heterocephalus glaber (naked mole-rat) : Gc (GC vitamin D binding protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl471,741,696 - 71,804,041 (-)EnsemblGRCh38hg38GRCh38
GRCh38471,741,693 - 71,805,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37472,607,410 - 72,671,237 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36472,826,274 - 72,868,752 (-)NCBINCBI36hg18NCBI36
Build 34472,972,446 - 73,014,923NCBI
Celera469,964,129 - 70,006,624 (-)NCBI
Cytogenetic Map4q13.3NCBI
HuRef468,412,706 - 68,476,557 (-)NCBIHuRef
CHM1_1472,643,398 - 72,707,216 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736902
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.