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Gene: HRG (histidine rich glycoprotein) Homo sapiens
Symbol: HRG
Name: histidine rich glycoprotein
Description: Exhibits several functions, including anion binding activity; heme binding activity; and zinc ion binding activity. Involved in several processes, including negative regulation of lamellipodium assembly; negative regulation of vascular endothelial growth factor signaling pathway; and positive regulation of focal adhesion assembly. Localizes to the cell surface and extracellular region. Implicated in thrombophilia and thrombosis. Biomarker of pancreatic adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp779H1622; histidine-proline-rich glycoprotein; histidine-rich glycoprotein; HPRG; HRGP; THPH11
Mus musculus (house mouse) : Hrg (histidine-rich glycoprotein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hrg (histidine-rich glycoprotein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hrg (histidine rich glycoprotein)
Pan paniscus (bonobo/pygmy chimpanzee) : HRG (histidine rich glycoprotein)
Canis lupus familiaris (dog) : HRG (histidine rich glycoprotein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hrg (histidine rich glycoprotein)
Sus scrofa (pig) : HRG (histidine rich glycoprotein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383186,665,975 - 186,678,235 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373186,383,747 - 186,396,023 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363187,866,492 - 187,878,717 (+)NCBINCBI36hg18NCBI36
Build 343187,866,499 - 187,878,724NCBI
Celera3184,820,230 - 184,832,456 (+)NCBI
Cytogenetic Map3q27.3NCBI
HuRef3183,793,470 - 183,805,692 (+)NCBIHuRef
CHM1_13186,347,695 - 186,359,980 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HRG
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736906
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.