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Gene: GNAS (GNAS complex locus) Homo sapiens
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Symbol: GNAS
Name: GNAS complex locus
Description: Predicted to have several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase activator activity; and signaling receptor binding activity. Involved in several processes, including hair follicle placode formation; platelet aggregation; and positive regulation of cAMP-mediated signaling. Localizes to several cellular components, including the cytosol; perinuclear region of cytoplasm; and trans-Golgi network membrane. Implicated in several diseases, including McCune Albright syndrome; cholangiocarcinoma; obesity; pituitary adenoma; and pseudohypoparathyroidism (multiple). Biomarker of Alzheimer's disease; pancreatic cancer; and pseudohypoparathyroidism type IB.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALEX; adenylate cyclase-stimulating G alpha protein; AHO; alternative gene product encoded by XL-exon; C20orf45; dJ309F20.1.1; dJ806M20.3.3; extra large alphas protein; G protein subunit alpha S; GNAS1; GPSA; GSA; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; MGC33735; NESP; NESP55; neuroendocrine secretory protein; PHP1A; PHP1B; PHP1C; PITA3; POH; SCG6; secretogranin VI; SgVI
Orthologs:
Mus musculus (house mouse) : Gnas (GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gnas (GNAS complex locus)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : GNAS (GNAS complex locus)
Canis lupus familiaris (dog) : GNAS (GNAS complex locus)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnas (GNAS complex locus)
Sus scrofa (pig) : GNAS (GNAS complex locus)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,839,681 - 58,911,196 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372057,414,756 - 57,486,250 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,848,190 - 56,919,645 (+)NCBINCBI36hg18NCBI36
Build 342056,900,129 - 56,919,640NCBI
Celera2054,155,257 - 54,226,691 (+)NCBI
Cytogenetic Map20q13.32NCBI
HuRef2054,201,757 - 54,273,094 (+)NCBIHuRef
CHM1_12057,316,663 - 57,387,668 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Candidate Gene Status
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Sequence

Nucleotide Sequences
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