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Gene: ABCB4 (ATP binding cassette subfamily B member 4) Homo sapiens
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Symbol: ABCB4
Name: ATP binding cassette subfamily B member 4
Description: Exhibits ATPase-coupled transmembrane transporter activity and phosphatidylcholine floppase activity. Involved in several processes, including cellular response to bile acid; phospholipid translocation; and positive regulation of lipid transport. Localizes to several cellular components, including actin cytoskeleton; apical plasma membrane; and focal adhesion. Implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC21; ATP-binding cassette sub-family B member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4; GBD1; ICP3; MDR2; MDR2/3; MDR3; multidrug resistance protein 3; multiple drug resistance 3; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein 3; P-glycoprotein-3/multiple drug resistance-3; PFIC-3; PGY3; phosphatidylcholine translocator ABCB4
Orthologs:
Mus musculus (house mouse) : Abcb4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Abcb4 (ATP binding cassette subfamily B member 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ABCB4 (ATP binding cassette subfamily B member 4)
Canis lupus familiaris (dog) : ABCB4 (ATP binding cassette subfamily B member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcb4 (ATP binding cassette subfamily B member 4)
Sus scrofa (pig) : ABCB4 (ATP binding cassette subfamily B member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl787,401,697 - 87,480,435 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl787,401,696 - 87,480,435 (-)EnsemblGRCh38hg38GRCh38
GRCh38787,398,988 - 87,476,722 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37787,031,361 - 87,105,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,869,297 - 86,942,955 (-)NCBINCBI36hg18NCBI36
Build 34786,676,016 - 86,754,402NCBI
Celera781,736,239 - 81,809,903 (-)NCBI
Cytogenetic Map7q21.12NCBI
HuRef781,642,357 - 81,716,022 (-)NCBIHuRef
CHM1_1786,961,467 - 87,035,121 (-)NCBICHM1_1
CRA_TCAGchr7v2786,362,871 - 86,436,531 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ABCB4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736946
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.