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Gene: PHB (prohibitin) Homo sapiens
Symbol: PHB
Name: prohibitin
Description: Exhibits several functions, including complement binding activity; histone deacetylase binding activity; and protein C-terminus binding activity. Involved in several processes, including progesterone receptor signaling pathway; regulation of signal transduction; and regulation of transcription, DNA-templated. Localizes to several cellular components, including the cell surface; early endosome; and mitochondrial inner membrane. Implicated in breast cancer and sporadic breast cancer. Biomarker of cervix uteri carcinoma in situ; prostate carcinoma in situ; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; HEL-215; HEL-S-54e; PHB1
Mus musculus (house mouse) : Phb (prohibitin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Phb (prohibitin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phb (prohibitin)
Pan paniscus (bonobo/pygmy chimpanzee) : PHB (prohibitin)
Canis lupus familiaris (dog) : PHB (prohibitin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phb (prohibitin)
Sus scrofa (pig) : PHB (prohibitin)
more info ...
Related Pseudogenes: PHBP1   PHBP10   PHBP11   PHBP12   PHBP13   PHBP14   PHBP15   PHBP17   PHBP18   PHBP19   PHBP2   PHBP20   PHBP21   PHBP3   PHBP4   PHBP5   PHBP6   PHBP7   PHBP8   PHBP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381749,404,048 - 49,414,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371747,481,410 - 47,492,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,836,419 - 44,847,241 (-)NCBINCBI36hg18NCBI36
Build 341744,836,418 - 44,847,241NCBI
Celera1743,936,440 - 43,947,262 (-)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1742,846,458 - 42,857,310 (-)NCBIHuRef
CHM1_11747,546,565 - 47,557,421 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PHB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736948
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.