Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PHB (prohibitin) Homo sapiens
Analyze
Symbol: PHB
Name: prohibitin
Description: Exhibits several functions, including complement binding activity; histone deacetylase binding activity; and protein C-terminus binding activity. Involved in several processes, including progesterone receptor signaling pathway; regulation of signal transduction; and regulation of transcription, DNA-templated. Localizes to several cellular components, including the cell surface; early endosome; and mitochondrial inner membrane. Implicated in breast cancer and sporadic breast cancer. Biomarker of cervix uteri carcinoma in situ; prostate carcinoma in situ; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; HEL-215; HEL-S-54e; PHB1
Orthologs:
Mus musculus (house mouse) : Phb (prohibitin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Phb (prohibitin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phb (prohibitin)
Pan paniscus (bonobo/pygmy chimpanzee) : PHB (prohibitin)
Canis lupus familiaris (dog) : PHB (prohibitin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phb (prohibitin)
Sus scrofa (pig) : PHB (prohibitin)
more info ...
Related Pseudogenes: PHBP1   PHBP10   PHBP11   PHBP12   PHBP13   PHBP14   PHBP15   PHBP17   PHBP18   PHBP19   PHBP2   PHBP20   PHBP21   PHBP3   PHBP4   PHBP5   PHBP6   PHBP7   PHBP8   PHBP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,404,048 - 49,414,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371747,481,410 - 47,492,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,836,419 - 44,847,241 (-)NCBINCBI36hg18NCBI36
Build 341744,836,418 - 44,847,241NCBI
Celera1743,936,440 - 43,947,262 (-)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1742,846,458 - 42,857,310 (-)NCBIHuRef
CHM1_11747,546,565 - 47,557,421 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PHB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736948
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.