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Gene: VTN (vitronectin) Homo sapiens
Symbol: VTN
Name: vitronectin
Description: Exhibits integrin binding activity. Involved in several processes, including positive regulation of smooth muscle cell migration; regulation of cellular protein metabolic process; and smooth muscle cell-matrix adhesion. Localizes to collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Biomarker of coronary artery disease and diabetic retinopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: complement S-protein; epibolin; S-protein; serum spreading factor; serum-spreading factor; somatomedin B; V75; vitronectin (serum spreading factor, somatomedin B, complement S-protein); VN; VNT
Mus musculus (house mouse) : Vtn (vitronectin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vtn (vitronectin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vtn (vitronectin)
Pan paniscus (bonobo/pygmy chimpanzee) : VTN (vitronectin)
Canis lupus familiaris (dog) : VTN (vitronectin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vtn (vitronectin)
Sus scrofa (pig) : VTN (vitronectin)
Chlorocebus sabaeus (African green monkey) : VTN (vitronectin)
Heterocephalus glaber (naked mole-rat) : Vtn (vitronectin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1728,367,284 - 28,373,091 (-)EnsemblGRCh38hg38GRCh38
GRCh381728,367,284 - 28,370,307 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371726,694,298 - 26,697,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,718,425 - 23,721,500 (-)NCBINCBI36hg18NCBI36
Build 341723,718,424 - 23,721,844NCBI
Celera1723,556,056 - 23,559,131 (-)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1722,902,707 - 22,905,782 (-)NCBIHuRef
CHM1_11726,757,231 - 26,760,306 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on VTN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736955
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.