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Gene: Vtn (vitronectin) Mus musculus
Symbol: Vtn
Name: vitronectin
Description: Exhibits extracellular matrix binding activity. Involved in several processes, including cell-matrix adhesion; oligodendrocyte differentiation; and positive regulation of cell-substrate adhesion. Localizes to the extracellular matrix. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and retina. Orthologous to human VTN (vitronectin); PARTICIPATES IN forkhead class A signaling pathway; vascular endothelial growth factor signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI256434; S-protein; serum-spreading factor; Vn
Homo sapiens (human) : VTN (vitronectin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Vtn (vitronectin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vtn (vitronectin)
Pan paniscus (bonobo/pygmy chimpanzee) : VTN (vitronectin)
Canis lupus familiaris (dog) : VTN (vitronectin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vtn (vitronectin)
Sus scrofa (pig) : VTN (vitronectin)
Chlorocebus sabaeus (green monkey) : VTN (vitronectin)
Heterocephalus glaber (naked mole-rat) : Vtn (vitronectin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1178,499,091 - 78,502,324 (+)Ensembl
GRCm381178,499,120 - 78,502,325 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371178,312,622 - 78,315,827 (+)NCBIGRCm37mm9NCBIm37
MGSCv361178,315,481 - 78,318,519 (+)NCBImm8
Celera1188,131,193 - 88,134,398 (+)NCBICelera
Cytogenetic Map11 B5NCBI
cM Map1146.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Vtn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736956
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.