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Gene: Lhx3 (LIM homeobox protein 3) Mus musculus
Symbol: Lhx3
Name: LIM homeobox protein 3
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and RNA polymerase II transcription factor binding activity. Involved in several processes, including nervous system development; placenta development; and positive regulation of transcription by RNA polymerase II. Localizes to the transcription factor complex. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in panhypopituitarism. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human LHX3 (LIM homeobox 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein LIM-3; homeobox protein P-LIM; LIM homeo box protein 3; LIM/homeobox protein Lhx3; Lim3; mLim-3; mLIM3; P-LIM
Homo sapiens (human) : LHX3 (LIM homeobox 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lhx3 (LIM homeobox 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lhx3 (LIM homeobox 3)
Pan paniscus (bonobo/pygmy chimpanzee) : LHX3 (LIM homeobox 3)
Canis lupus familiaris (dog) : LHX3 (LIM homeobox 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lhx3 (LIM homeobox 3)
Sus scrofa (pig) : LHX3 (LIM homeobox 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38226,200,212 - 26,208,249 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37226,055,732 - 26,062,076 (-)NCBIGRCm37mm9NCBIm37
MGSCv36226,022,956 - 26,030,258 (-)NCBImm8
Celera225,922,727 - 25,930,762 (-)NCBICelera
Cytogenetic Map2 A3NCBI
cM Map218.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lhx3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736998
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.