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Gene: HAND1 (heart and neural crest derivatives expressed 1) Homo sapiens
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Symbol: HAND1
Name: heart and neural crest derivatives expressed 1
Description: The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHa27; class A basic helix-loop-helix protein 27; eHand; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; heart- and neural crest derivatives-expressed protein 1; Hxt; Thing1
Orthologs:
Mus musculus (house mouse) : Hand1 (heart and neural crest derivatives expressed 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hand1 (heart and neural crest derivatives expressed 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hand1 (heart and neural crest derivatives expressed 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HAND1 (heart and neural crest derivatives expressed 1)
Canis lupus familiaris (dog) : HAND1 (heart and neural crest derivatives expressed 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hand1 (heart and neural crest derivatives expressed 1)
Sus scrofa (pig) : HAND1 (heart and neural crest derivatives expressed 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385154,474,972 - 154,478,264 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375153,854,532 - 153,857,824 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365153,834,725 - 153,838,017 (-)NCBINCBI36hg18NCBI36
Build 345153,834,725 - 153,838,017NCBI
Celera5149,930,197 - 149,933,489 (-)NCBI
Cytogenetic Map5q33.2NCBI
HuRef5148,995,253 - 148,998,545 (-)NCBIHuRef
CHM1_15153,286,949 - 153,290,241 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HAND1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737010
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.