Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: TLR4 (toll like receptor 4) Homo sapiens
Analyze
Symbol: TLR4
Name: toll like receptor 4
Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARMD10; CD284; homolog of Drosophila toll; hToll; TLR-4; TOLL; toll-like receptor 4
Orthologs:
Mus musculus (house mouse) : Tlr4 (toll-like receptor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr4 (toll-like receptor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr4 (toll like receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR4 (toll like receptor 4)
Canis lupus familiaris (dog) : TLR4 (toll like receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr4 (toll like receptor 4)
Sus scrofa (pig) : TLR4 (toll like receptor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389117,704,403 - 117,724,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379120,466,453 - 120,479,769 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369119,506,431 - 119,519,589 (+)NCBINCBI36hg18NCBI36
Build 349117,546,137 - 117,556,781NCBI
Celera991,114,228 - 91,127,535 (+)NCBI
Cytogenetic Map9q33.1NCBI
HuRef990,084,535 - 90,097,850 (+)NCBIHuRef
CHM1_19120,614,005 - 120,627,323 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences