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Gene: Tlr4 (toll-like receptor 4) Mus musculus
Symbol: Tlr4
Name: toll-like receptor 4
Description: Exhibits lipopolysaccharide immune receptor activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of cytokine production; and regulation of intracellular signal transduction. Localizes to plasma membrane and receptor complex. Predicted to colocalize with membrane raft. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Is expressed in cumulus oophorus; early embryo; inner cell mass; and intestine. Orthologous to human TLR4 (toll like receptor 4).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Toll like receptor 4
Homo sapiens (human) : TLR4 (toll like receptor 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tlr4 (toll-like receptor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr4 (toll like receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR4 (toll like receptor 4)
Canis lupus familiaris (dog) : TLR4 (toll like receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr4 (toll like receptor 4)
Sus scrofa (pig) : TLR4 (toll like receptor 4)
Chlorocebus sabaeus (African green monkey) : TLR4 (toll like receptor 4)
Heterocephalus glaber (naked mole-rat) : Tlr4 (toll like receptor 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl466,827,584 - 66,930,284 (+)EnsemblGRCm38mm10GRCm38
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBImm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated