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Gene: ACAT1 (acetyl-CoA acetyltransferase 1) Homo sapiens
Symbol: ACAT1
Name: acetyl-CoA acetyltransferase 1
CRRD ID: 737017
Description: Exhibits acetyl-CoA C-acetyltransferase activity and potassium ion binding activity. Involved in isoleucine catabolic process; ketone body catabolic process; and purine nucleoside bisphosphate metabolic process. Localizes to mitochondrion. Implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Biomarker of arteriosclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACAT; acetoacetyl Coenzyme A thiolase; acetoacetyl-CoA thiolase; acetyl-CoA acetyltransferase, mitochondrial; acetyl-Coenzyme A acetyltransferase 1; MAT; mitochondrial acetoacetyl-CoA thiolase; T2; testicular tissue protein Li 198; THIL
Mus musculus (house mouse) : Acat1 (acetyl-Coenzyme A acetyltransferase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Acat1 (acetyl-CoA acetyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acat1 (acetyl-CoA acetyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ACAT1 (acetyl-CoA acetyltransferase 1)
Canis lupus familiaris (dog) : ACAT1 (acetyl-CoA acetyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acat1 (acetyl-CoA acetyltransferase 1)
Sus scrofa (pig) : ACAT1 (acetyl-CoA acetyltransferase 1)
Chlorocebus sabaeus (African green monkey) : ACAT1 (acetyl-CoA acetyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Acat1 (acetyl-CoA acetyltransferase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: ACAT1 (Gene ID: 38) and SOAT1 (Gene ID: 6646) share the ACAT1 symbol/alias in common. ACAT1 is a widely used alternative name for sterol O-acyltransferase 1 (SOAT1), which can be confused with the official symbol for ACAT1 (acetyl-CoA acetyltransferase 1, GeneID 38). [01 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl11108,116,695 - 108,147,603 (+)EnsemblGRCh38hg38GRCh38
GRCh3811108,116,705 - 108,148,822 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711107,992,258 - 108,018,895 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,497,468 - 107,523,485 (+)NCBINCBI36hg18NCBI36
Build 3411107,497,467 - 107,523,485NCBI
Celera11105,147,145 - 105,173,805 (+)NCBI
Cytogenetic Map11q22.3NCBI
HuRef11103,917,783 - 103,944,520 (+)NCBIHuRef
CHM1_111107,875,420 - 107,902,046 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ACAT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 737017
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.